Metabolic targets for cancer therapy

Key Points During the past decade, the metabolic alterations that intimately accompany oncogenesis and tumour progression have been intensively investigated, generating great expectations on the development of novel antineoplastic agents that would selectively target the metabolism of malignant cell...

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Veröffentlicht in:	Nature reviews. Drug discovery 2013-11, Vol.12 (11), p.829-846
Hauptverfasser:	Galluzzi, Lorenzo, Kepp, Oliver, Heiden, Matthew G. Vander, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/154/109 631/67/2327 Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomedicine Biotechnology Cancer Cancer Research Care and treatment Cell metabolism Cell Transformation, Neoplastic - metabolism Humans Medicinal Chemistry Models, Biological Molecular Medicine Molecular Targeted Therapy - methods Neoplasms - drug therapy Neoplasms - metabolism Neoplastic processes Observations Pharmacology/Toxicology Physiological aspects review-article Signal Transduction - drug effects
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