Abstract 4794: Oligoamide-based mimics of double-stranded B-DNA as a new class of DNA topoisomerase I catalytic inhibitors

Since the discovery of Topoisomerase I as a specific target for the treatment of cancers more than 30 years ago, only two inhibitors derived from the natural compound camptothecin (CPT) have been approved in the clinic for the treatment of colon, lung and ovarian cancers: topotecan and irinotecan. T...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.4794-4794
Hauptverfasser:	Pourquier, Philippe, Ziach, Krzysztof, Chollet, Céline, Parissi, Vincent, Marchivie, Mathieu, Prabhakaran, Panchami, Bose, Partha P., Laxmi-Reddy, Katta, Godde, Frédéric, Chaignepain, Stéphane, Schmitter, Jean Marie, Huc, Ivan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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