Altered Neutrophil Trafficking During Sepsis

In sepsis, dysregulation of the inflammatory system is well known, as reflected in excessive inflammatory mediator production, complement activation, and appearance of defects in phagocytic cells. In the current study sepsis was induced in rats by cecal ligation/puncture. Early in sepsis the beta(1)...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-07, Vol.169 (1), p.307-314
Hauptverfasser:	Guo, Ren-Feng, Riedemann, Niels C, Laudes, Ines J, Sarma, Vidya J, Kunkel, Robin G, Dilley, Kari A, Paulauskis, Joseph D, Ward, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology CD18 Antigens - biosynthesis CD18 Antigens - blood CD18 Antigens - immunology Complement C5a - antagonists & inhibitors Complement C5a - immunology Complement C5a - pharmacology Disease Models, Animal Fibronectins - metabolism Flow Cytometry Immunoglobulin G - administration & dosage Infusions, Intravenous Integrin beta1 - biosynthesis Integrin beta1 - blood Integrin beta1 - immunology Ligation Lung - enzymology Lung - pathology Male Neutrophil Infiltration - drug effects Neutrophil Infiltration - immunology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Peroxidase - metabolism Punctures Rats Rats, Long-Evans Sepsis - blood Sepsis - enzymology Sepsis - immunology Sepsis - pathology Tetradecanoylphorbol Acetate - pharmacology
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