Internal initiation sites of de novo RNA synthesis within the hepatitis C virus polypyrimidine tract

A variety of 3 ′-untranslated regions (UTRs) were cloned from infectious hepatitis C virus human samples and examined in NS5B polymerase de novo initiation reactions. We isolated and characterized four distinct 3 ′-UTRs that harbor the conserved terminal 98 nucleotides, but have poly(U/UC) tracts of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-07, Vol.295 (3), p.682-688
Hauptverfasser:	Pellerin, Charles, Lefebvre, Sylvain, Little, Michael J, McKercher, Ginette, Lamarre, Daniel, Kukolj, George
Format:	Artikel
Sprache:	eng
Schlagworte:	3 ′-Untranslated region 3' Untranslated Regions Base Sequence Cloning, Molecular De novo RNA synthesis Dose-Response Relationship, Drug Guanosine Triphosphate - metabolism HCV Hepacivirus - genetics Hepatitis C virus Models, Genetic Molecular Sequence Data NS5B Plasmids - metabolism Repetitive Sequences, Nucleic Acid Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA-dependent RNA polymerase Viral Nonstructural Proteins - genetics
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