Humic Acid Induces Apoptosis in Human Endothelial Cells

Humic acid (HA) has been implicated as an etiologic factor in the vasculopathy of Blackfoot disease. In this study, the ability of HA to induce apoptosis was studied in cultured human umbilical vein endothelial cells. Treatment of endothelial cells with a variety of concentrations of HA (50–200 μg/m...

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Veröffentlicht in:	Toxicology and applied pharmacology 2002-07, Vol.182 (1), p.34-43
Hauptverfasser:	Hseu, You-Cheng, Huang, Hurng-Wern, Wang, Shi-Ying, Chen, Hwei-Yan, Lu, Fung-Jou, Gau, Rung-Jiun, Yang, Hsin-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis - drug effects bcl-2-Associated X Protein Biological and medical sciences blackfoot disease Blood and lymphatic vessels Calcium - metabolism Cardiology. Vascular system Caspase 1 - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous DNA Fragmentation - drug effects Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme-Linked Immunosorbent Assay Food toxicology Genes, bcl-2 - drug effects Humans humic acid Humic Substances - toxicity In Situ Nick-End Labeling Medical sciences Peripheral Vascular Diseases - chemically induced Peripheral Vascular Diseases - metabolism Peripheral Vascular Diseases - pathology Polymerase Chain Reaction Proto-Oncogene Proteins - pharmacology Proto-Oncogene Proteins c-bcl-2 Superoxide Dismutase - pharmacology Toxicology Tumor Suppressor Protein p53 - metabolism Vitamin A - pharmacology Vitamin E - pharmacology
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