Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach

ABSTRACT We report the successful implementation of a novel melt co-extrusion process to fabricate ca. 1 μm diameter fibers of poly(caprolactone) (PCL) containing the antifungal compound clotrimazole in concentrations between 4 and 8 wt%. The process involves co-extrusion of a clotrimazole-loaded PC...

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Veröffentlicht in:	AAPS PharmSciTech 2017-08, Vol.18 (6), p.1917-1924
Hauptverfasser:	Mofidfar, Mohammad, Wang, Jia, Long, Lisa, Hager, Christopher L., Vareechon, Chairut, Pearlman, Eric, Baer, Eric, Ghannoum, Mahmoud, Wnek, Gary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Candida albicans - drug effects Candida albicans - metabolism Caproates - chemistry Caproates - pharmacokinetics Chemistry, Pharmaceutical - methods Clotrimazole - chemistry Clotrimazole - pharmacokinetics Drug Compounding Drug Liberation - drug effects Drug Liberation - physiology Lactones - chemistry Lactones - pharmacokinetics Mice Nanofibers - chemistry Pharmacology/Toxicology Pharmacy Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polymers - chemistry Polymers - pharmacokinetics Research Article Trichophyton - drug effects Trichophyton - metabolism
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