Microemulsion Transdermal Formulation for Simultaneous Delivery of Valsartan and Nifedipine: Formulation by Design

The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of two poorly soluble antihypertensive drugs. Surface response methodology of Box-Behnken design was utilized to evalua...

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Veröffentlicht in:	AAPS PharmSciTech 2017-08, Vol.18 (6), p.1901-1916
Hauptverfasser:	Sood, Jatin, Sapra, Bharti, Tiwary, Ashok K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Antihypertensive Agents - administration & dosage Antihypertensive Agents - chemistry Antihypertensive Agents - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Drug Compounding Drug Delivery Systems - methods Emulsions Excipients - administration & dosage Excipients - chemistry Excipients - metabolism Male Nifedipine - administration & dosage Nifedipine - chemistry Nifedipine - metabolism Oils - administration & dosage Oils - chemistry Oils - metabolism Organ Culture Techniques Particle Size Pharmacology/Toxicology Pharmacy Rats Research Article Skin Absorption Surface-Active Agents - administration & dosage Surface-Active Agents - chemistry Surface-Active Agents - metabolism Valsartan - administration & dosage Valsartan - chemistry Valsartan - metabolism
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