Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue
Bone regeneration is considered as an unmet clinical need, the aim of this study is to investigate the osteogenic potential of three different mesenchymal stem cells (MSCs) derived from human bone marrow (BM-MSCs), umbilical cord Wharton's jelly (UC-MSCs), and adipose (AD-MSCs) seeded on a rece...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2018-01, Vol.106 (1), p.61-72 |
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| creator | Kargozar, Saeid Mozafari, Masoud Hashemian, Seyed Jafar Brouki Milan, Peiman Hamzehlou, Sepideh Soleimani, Mansooreh Joghataei, Mohammad Taghi Gholipourmalekabadi, Mazaher Korourian, Alireza Mousavizadeh, Kazem Seifalian, Alexander M |
| description | Bone regeneration is considered as an unmet clinical need, the aim of this study is to investigate the osteogenic potential of three different mesenchymal stem cells (MSCs) derived from human bone marrow (BM-MSCs), umbilical cord Wharton's jelly (UC-MSCs), and adipose (AD-MSCs) seeded on a recently developed nanocomposite scaffold (bioactive glass/gelatin) implanted in rat animal models with critical size calvarial defects. In this study, after isolation, culture, and characterization, the MSCs were expanded and seeded on the scaffolds for in vitro and in vivo studies. The adhesion, proliferation, and viability of the cells on the scaffolds evaluated in vitro, showed that the scaffolds were biocompatible for further examinations. In order to evaluate the scaffolds in vivo, rat animal models with critical size calvarial defects were randomly categorized in four groups and treated with the scaffolds. The animals were sacrificed at the time points of 4 and 12 weeks of post-implantation, bone healing process were investigated. The histological and immunohistological observations showed (p < 0.01) higher osteogenesis capacity in the group treated with BM-MSCs/scaffolds compared to the other groups. However, the formation of new angiogenesis was evidently higher in the defects filled with UC-MSCs/scaffolds. This preliminary study provides promising data for further clinical trials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 61-72, 2018. |
| doi_str_mv | 10.1002/jbm.b.33814 |
| format | Article |
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In this study, after isolation, culture, and characterization, the MSCs were expanded and seeded on the scaffolds for in vitro and in vivo studies. The adhesion, proliferation, and viability of the cells on the scaffolds evaluated in vitro, showed that the scaffolds were biocompatible for further examinations. In order to evaluate the scaffolds in vivo, rat animal models with critical size calvarial defects were randomly categorized in four groups and treated with the scaffolds. The animals were sacrificed at the time points of 4 and 12 weeks of post-implantation, bone healing process were investigated. The histological and immunohistological observations showed (p < 0.01) higher osteogenesis capacity in the group treated with BM-MSCs/scaffolds compared to the other groups. However, the formation of new angiogenesis was evidently higher in the defects filled with UC-MSCs/scaffolds. This preliminary study provides promising data for further clinical trials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 61-72, 2018.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.33814</identifier><identifier>PMID: 27862947</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adhesion tests ; Adipose tissue ; Angiogenesis ; Animal models ; Biocompatibility ; Biological activity ; Biomedical materials ; Bone growth ; Bone healing ; Bone marrow ; Cell culture ; Cell proliferation ; Clinical trials ; Comparative studies ; Defects ; Gelatin ; Implantation ; In vivo methods and tests ; Materials research ; Materials science ; Medical research ; Mesenchymal stem cells ; Mesenchyme ; Nanocomposites ; Osteogenesis ; Regeneration ; Regeneration (physiology) ; Scaffolds ; Stem cell transplantation ; Stem cells ; Studies ; Surgical implants ; Umbilical cord</subject><ispartof>Journal of biomedical materials research. 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Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>Bone regeneration is considered as an unmet clinical need, the aim of this study is to investigate the osteogenic potential of three different mesenchymal stem cells (MSCs) derived from human bone marrow (BM-MSCs), umbilical cord Wharton's jelly (UC-MSCs), and adipose (AD-MSCs) seeded on a recently developed nanocomposite scaffold (bioactive glass/gelatin) implanted in rat animal models with critical size calvarial defects. In this study, after isolation, culture, and characterization, the MSCs were expanded and seeded on the scaffolds for in vitro and in vivo studies. The adhesion, proliferation, and viability of the cells on the scaffolds evaluated in vitro, showed that the scaffolds were biocompatible for further examinations. In order to evaluate the scaffolds in vivo, rat animal models with critical size calvarial defects were randomly categorized in four groups and treated with the scaffolds. The animals were sacrificed at the time points of 4 and 12 weeks of post-implantation, bone healing process were investigated. The histological and immunohistological observations showed (p < 0.01) higher osteogenesis capacity in the group treated with BM-MSCs/scaffolds compared to the other groups. However, the formation of new angiogenesis was evidently higher in the defects filled with UC-MSCs/scaffolds. This preliminary study provides promising data for further clinical trials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 61-72, 2018.</description><subject>Adhesion tests</subject><subject>Adipose tissue</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone marrow</subject><subject>Cell culture</subject><subject>Cell proliferation</subject><subject>Clinical trials</subject><subject>Comparative studies</subject><subject>Defects</subject><subject>Gelatin</subject><subject>Implantation</subject><subject>In vivo methods and tests</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Medical research</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchyme</subject><subject>Nanocomposites</subject><subject>Osteogenesis</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Surgical implants</subject><subject>Umbilical cord</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUuLFDEQgBtR3HX15F0KPCi4Myadnk63t2XxBQt7UTw2laTiZOgkY5JW5jf6p8zsrit4qqL46sXXNM85W3PG2rc75ddqLcTAuwfNKd9s2lU3DvzhfS7FSfMk512Fe7YRj5uTVg59O3bytPl9nQvF7xSchn0sFIrDGaKFWvagaZ7zKhMZMqBcRF3cT4KAIero9zG7QpA1Whtnk9_BBRzLmPAGy2UxB1BUfhEF2C4eA3jKFPT24OuWfyvAUKodBmyKHlQMdA6LV252unI6JgPftphKDK8y7GrH4RwwGEDj6hEExeW80NPmkcU507O7eNZ8_fD-y-Wn1dX1x8-XF1cr3bWsrKSy_Ug911qalqNUvDdMDmy0muNAjMmxt6NR2OHYYdsyMSAyZXoajbSsE2fN69u5-xR_LJTL5F0-_oGB4pInPnR8YEK0oqIv_0N3cUmhXjfx6kWKakJW6s0tpVPMOZGd9sl5TIeJs-noeKqOJzXdOK70i7uZi_Jk7tm_UsUfuYynbA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kargozar, Saeid</creator><creator>Mozafari, Masoud</creator><creator>Hashemian, Seyed Jafar</creator><creator>Brouki Milan, Peiman</creator><creator>Hamzehlou, Sepideh</creator><creator>Soleimani, Mansooreh</creator><creator>Joghataei, Mohammad Taghi</creator><creator>Gholipourmalekabadi, Mazaher</creator><creator>Korourian, Alireza</creator><creator>Mousavizadeh, Kazem</creator><creator>Seifalian, Alexander M</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8334-9376</orcidid><orcidid>https://orcid.org/0000-0002-0232-352X</orcidid></search><sort><creationdate>20180101</creationdate><title>Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue</title><author>Kargozar, Saeid ; Mozafari, Masoud ; Hashemian, Seyed Jafar ; Brouki Milan, Peiman ; Hamzehlou, Sepideh ; Soleimani, Mansooreh ; Joghataei, Mohammad Taghi ; Gholipourmalekabadi, Mazaher ; Korourian, Alireza ; Mousavizadeh, Kazem ; Seifalian, Alexander M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-7bf69e61cc7d21a7b16d07809fc1a8e00796f9dba4a94a22038aa0bd6e9d7f043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adhesion tests</topic><topic>Adipose tissue</topic><topic>Angiogenesis</topic><topic>Animal models</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>Bone marrow</topic><topic>Cell culture</topic><topic>Cell proliferation</topic><topic>Clinical trials</topic><topic>Comparative studies</topic><topic>Defects</topic><topic>Gelatin</topic><topic>Implantation</topic><topic>In vivo methods and tests</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Medical research</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchyme</topic><topic>Nanocomposites</topic><topic>Osteogenesis</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Scaffolds</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Surgical implants</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kargozar, Saeid</creatorcontrib><creatorcontrib>Mozafari, Masoud</creatorcontrib><creatorcontrib>Hashemian, Seyed Jafar</creatorcontrib><creatorcontrib>Brouki Milan, Peiman</creatorcontrib><creatorcontrib>Hamzehlou, Sepideh</creatorcontrib><creatorcontrib>Soleimani, Mansooreh</creatorcontrib><creatorcontrib>Joghataei, Mohammad Taghi</creatorcontrib><creatorcontrib>Gholipourmalekabadi, Mazaher</creatorcontrib><creatorcontrib>Korourian, Alireza</creatorcontrib><creatorcontrib>Mousavizadeh, Kazem</creatorcontrib><creatorcontrib>Seifalian, Alexander M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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The adhesion, proliferation, and viability of the cells on the scaffolds evaluated in vitro, showed that the scaffolds were biocompatible for further examinations. In order to evaluate the scaffolds in vivo, rat animal models with critical size calvarial defects were randomly categorized in four groups and treated with the scaffolds. The animals were sacrificed at the time points of 4 and 12 weeks of post-implantation, bone healing process were investigated. The histological and immunohistological observations showed (p < 0.01) higher osteogenesis capacity in the group treated with BM-MSCs/scaffolds compared to the other groups. However, the formation of new angiogenesis was evidently higher in the defects filled with UC-MSCs/scaffolds. This preliminary study provides promising data for further clinical trials. © 2016 Wiley Periodicals, Inc. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adhesion tests Adipose tissue Angiogenesis Animal models Biocompatibility Biological activity Biomedical materials Bone growth Bone healing Bone marrow Cell culture Cell proliferation Clinical trials Comparative studies Defects Gelatin Implantation In vivo methods and tests Materials research Materials science Medical research Mesenchymal stem cells Mesenchyme Nanocomposites Osteogenesis Regeneration Regeneration (physiology) Scaffolds Stem cell transplantation Stem cells Studies Surgical implants Umbilical cord |
| title | Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue |
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