Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists

The human histamine H receptor (hH R) is subject to extensive gene splicing that gives rise to a large number of functional and nonfunctional isoforms. Despite the general acceptance that G protein-coupled receptors can adopt different ligand-induced conformations that give rise to biased signaling,...

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Veröffentlicht in:	Molecular pharmacology 2017-02, Vol.91 (2), p.87-99
Hauptverfasser:	Riddy, Darren M, Cook, Anna E, Diepenhorst, Natalie A, Bosnyak, Sanja, Brady, Ryan, Mannoury la Cour, Clotilde, Mocaer, Elisabeth, Summers, Roger J, Charman, William N, Sexton, Patrick M, Christopoulos, Arthur, Langmead, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay CHO Cells Cricetinae Cricetulus Cyclic AMP - metabolism Histamine Agonists - chemistry Histamine Agonists - pharmacology Humans Principal Component Analysis Protein Isoforms - metabolism Receptors, Histamine H3 - metabolism Sequence Deletion
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