Parthenolide Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in Human Osteosarcoma Cells

Background and Aim: Osteosarcoma is a devastating tumor of bone, primarily affecting adolescents. Parthenolide, a naturally occurring small molecule that interferes with NF-κB signaling, has recently attracted considerable attention because of its pharmacological action involving anti-cancer effects...

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Veröffentlicht in:	Cellular physiology and biochemistry 2016-01, Vol.40 (1-2), p.146-154
Hauptverfasser:	Yang, Chen, Yang, Qing Ou, Kong, Qing-Jie, Yuan, Wen, Ou Yang, Yue-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Autophagy - drug effects Caspase 3 - metabolism Cell Line, Tumor Humans Mitochondrial Degradation - drug effects Original Paper Osteosarcoma - enzymology Osteosarcoma - pathology Osteosarcoma cells Parthenolide Reactive Oxygen Species - metabolism Sesquiterpenes - pharmacology
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