Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies
Mitochondria have emerged as key participants in and regulators of myocardial injury during ischemia and reperfusion. This review examines the sites of damage to cardiac mitochondria during ischemia and focuses on the impact of these defects. The concept that mitochondrial damage during ischemia lea...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 2017-01, Vol.57 (1), p.535-565 |
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| container_title | Annual review of pharmacology and toxicology |
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| creator | Lesnefsky, Edward J Chen, Qun Tandler, Bernard Hoppel, Charles L |
| description | Mitochondria have emerged as key participants in and regulators of myocardial injury during ischemia and reperfusion. This review examines the sites of damage to cardiac mitochondria during ischemia and focuses on the impact of these defects. The concept that mitochondrial damage during ischemia leads to cardiac injury during reperfusion is addressed. The mechanisms that translate ischemic mitochondrial injury into cellular damage, during both ischemia and early reperfusion, are examined. Next, we discuss strategies that modulate and counteract these mechanisms of mitochondrial-driven injury. The new concept that mitochondria are not merely stochastic sites of oxidative and calcium-mediated injury but that they activate cellular responses of mitochondrial remodeling and cellular reactions that modulate the balance between cell death and recovery is reviewed, and the therapeutic implications of this concept are discussed. |
| doi_str_mv | 10.1146/annurev-pharmtox-010715-103335 |
| format | Article |
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| ispartof | Annual review of pharmacology and toxicology, 2017-01, Vol.57 (1), p.535-565 |
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| source | Annual Reviews; MEDLINE |
| subjects | Animals cardiolipin Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Cell Death - drug effects Cell Death - physiology Electron Transport - drug effects Electron Transport - physiology electron transport chain fatty acid oxidation Humans Ischemic Preconditioning, Myocardial - methods Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology oxidative phosphorylation oxidoreductase reactive oxygen species ubiquinol:cytochrome |
| title | Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies |
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