A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis

The modification of 5-hydroxyindoleacetic acid (5HIAA) by myeloperoxidase with a xanthine oxidase system was investigated by chromatographic analyses. Two major products were identified as a dimer and quinone (indoleacetate dione) of 5HIAA. The formation of a quinone moiety was also confirmed by che...

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Veröffentlicht in:	Free radical biology & medicine 2016-12, Vol.101, p.500-510
Hauptverfasser:	Kato, Yoji, Oki, Kota, Suga, Naoko, Ono, Shigeki, Ishisaka, Akari, Miura, Yoko, Kanazawa, Satoshi, Naito, Michitaka, Kitamoto, Noritoshi, Kettle, Anthony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxyindoleacetic acid Acetylcysteine - chemistry Aged Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - isolation & purification Antibody Aorta - chemistry Aorta - metabolism Aorta - pathology Atherosclerosis Atherosclerosis - blood Atherosclerosis - pathology Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Hydroxyindoleacetic Acid - chemistry Hydroxyindoleacetic Acid - metabolism Immunohistochemistry Male Microtomy Peroxidase - chemistry Peroxidase - metabolism Phenylenediamines Quinone Quinones - chemical synthesis Quinones - metabolism Serotonin Serotonin - chemistry Serotonin - metabolism Xanthine Oxidase - chemistry Xanthine Oxidase - metabolism
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