Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer immunology research 2016-12, Vol.4 (12), p.1038-1048
Hauptverfasser:	Awad, Mark M, Jones, Robert E, Liu, Hongye, Lizotte, Patrick H, Ivanova, Elena V, Kulkarni, Meghana, Herter-Sprie, Grit S, Liao, Xiaoyun, Santos, Abigail A, Bittinger, Mark A, Keogh, Lauren, Koyama, Shohei, Almonte, Christina, English, Jessie M, Barlow, Julianne, Richards, William G, Barbie, David A, Bass, Adam J, Rodig, Scott J, Hodi, F Stephen, Wucherpfennig, Kai W, Jänne, Pasi A, Sholl, Lynette M, Hammerman, Peter S, Wong, Kwok-Kin, Bueno, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - immunology Female Humans Male Mesothelioma - immunology Pleural Neoplasms - immunology T-Lymphocytes, Cytotoxic - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!