An Enantioselective Bidentate Auxiliary Directed Palladium-Catalyzed Benzylic C−H Arylation of Amines Using a BINOL Phosphate Ligand

A new enantioselective palladium(II)‐catalyzed benzylic C−H arylation reaction of amines is enabled by the bidentate picolinamide (PA) directing group. This reaction provides the first example of enantioselective benzylic γ‐C−H arylations of alkyl amines, and proceeds with up to 97 % ee. The 2,2′‐di...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-12, Vol.55 (49), p.15387-15391
Hauptverfasser:	Wang, Hao, Tong, Hua-Rong, He, Gang, Chen, Gong
Format:	Artikel
Sprache:	eng
Schlagworte:	arylations C−H activation enantioselectivity Ligands palladium reaction mechanism
Online-Zugang:	Volltext
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