Valproic Acid and Lithium Meditate Anti‐Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function

Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)‐3, and lithium, with inhibition activity mainly toward GSK‐3, are both prescribed in clinical as mood‐stabilizers and anticonvulsants for the control of bipolar disorder. This st...

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Veröffentlicht in:	Journal of cellular physiology 2017-05, Vol.232 (5), p.1176-1186
Hauptverfasser:	Leu, Sy‐Jye, Yang, Yi‐Yuan, Liu, Hsing‐Cheng, Cheng, Chieh‐Yu, Wu, Yu‐Chen, Huang, Ming‐Chyi, Lee, Yuen‐Lun, Chen, Chi‐Ching, Shen, Winston W., Liu, Ko‐Jiunn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antigens, CD - metabolism Arthritis, Experimental - drug therapy Cattle Cell differentiation Cell Differentiation - drug effects Cell Polarity - drug effects Cytokines - metabolism Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Inflammation - pathology Interleukin-10 - metabolism Interleukin-6 - secretion Interleukin-8 - metabolism Lipid Metabolism - drug effects Lipopolysaccharides Lithium Lithium Chloride - pharmacology Lithium Chloride - therapeutic use Mice Monocytes - cytology Th17 Cells - cytology Th17 Cells - drug effects Toll-Like Receptors - metabolism Tumor Necrosis Factor-alpha - metabolism Valproic Acid - pharmacology Valproic Acid - therapeutic use
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