Biochemical Characterization of a Beta Cell Membrane Fraction Antigenic for Autoreactive T Cell Clones

The two NOD-derived T cell clones, BDC-2.5 and BDC-6.9, are CD4+, Vβ4+, islet-specific, and diabetogenic. These two T cell clones show different response patterns to whole islet cell antigen, but were found to respond to the same fraction isolated from beta granule membranes. The clones were used to...

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Veröffentlicht in:	Journal of autoimmunity 2000-06, Vol.14 (4), p.343-351
Hauptverfasser:	Bergman, Barbara, McManaman, James L, Haskins, Kathryn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - immunology Antigens, Surface - isolation & purification Autoantigens - immunology Autoantigens - isolation & purification Biological and medical sciences Cell Membrane - chemistry Cell Membrane - immunology Chromatography, Gel Chromatography, Ion Exchange Clone Cells - immunology Detergents Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Electrophoresis, Polyacrylamide Gel Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epitopes, T-Lymphocyte - immunology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Islet cell antigens, autoreactive T cells Islets of Langerhans - chemistry Islets of Langerhans - immunology Male Medical sciences Membrane Proteins - immunology Membrane Proteins - isolation & purification Mice Mice, Inbred NOD Mice, SCID Solubility T-Lymphocytes - immunology
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