Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants
Study Objective. To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney‐pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin. Design. Retrospective chart review. Setting. University‐based tertiary care center. Patien...
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| Veröffentlicht in: | Pharmacotherapy 2002-02, Vol.22 (2), p.184-187 |
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| creator | Shullo, Michael A. Rose, Meredith L. Vivas, Carlos Jordan, Mark L. Scantlebury, Velma P. Jain, Ashok Corry, Robert J. Fung, John J. McCauley, Jerry Johnston, James Shapiro, Ron |
| description | Study Objective. To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney‐pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin.
Design. Retrospective chart review.
Setting. University‐based tertiary care center.
Patients. Thirteen patients who had received enoxaparin within 10 days of kidney or kidney‐pancreas transplantation.
Intervention. Medical records were reviewed, and data from patients who had received low‐dose aspirin 81 mg once/day and enoxaparin within 10 days of transplantation were collected.
Measurements and Main Results. Major bleeding events were defined as intracranial or retroperitoneal bleeding, or a decrease in hemoglobin of greater than 2 g/dl that was confirmed on repeat evaluation. Nine (69%) of the 13 patients had confirmed major bleeding events and required blood transfusions. Six of the nine patients had elevated serum creatinine levels.
Conclusion. The combination of enoxaparin and low‐dose aspirin early after kidney or kidney‐pancreas transplantation was associated with a high frequency of hemorrhagic events. Further evaluation is needed to determine the safety of enoxaparin in combination with aspirin after transplantation. |
| doi_str_mv | 10.1592/phco.22.3.184.33541 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18411971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18411971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4507-15584aaff879e43e42cef020d2bf1a603b9c94258d7051001d8aff3d062f12703</originalsourceid><addsrcrecordid>eNqNkE9v0zAcQC0EYmXwCZBQLnBL8M9_4vhYdWNFTFBNQ0NcLNexqSGJg51q67fHoRW7IlmyZb9nWw-h14Ar4JK8H3cmVIRUtIKGVZRyBk_QAhrBSwnAnqIFJkKUGOPmDL1I6SfGBGpGnqMzgIYKzsUC3a1tH2Lc6R_eFKvQj503evJhSEVwxeUQHvSoox8KPbTFMo1-XuexyZAdplTc-2lXfPLtYA_FbdRDGjud91-iZ053yb46zefo64fL29W6vP5y9XG1vC4N41iUwHnDtHauEdIyahkx1mGCW7J1oGtMt9JIRnjTCswBY2ibDNMW18QBEZieo3fHe8cYfu9tmlTvk7Fd_oQN-6RyGgApIIP0CJoYUorWqTH6XseDAqzmnmruqQhRdJbU357ZenO6fr_tbfvonAJm4O0J0MnozuUCxqdHjrJaSjFz8sjd-84e_udttVkvbwitZ7c8uj5N9uGfq-MvlU8FV3efr5T8doO_X2xA1fQPu16fmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18411971</pqid></control><display><type>article</type><title>Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Shullo, Michael A. ; Rose, Meredith L. ; Vivas, Carlos ; Jordan, Mark L. ; Scantlebury, Velma P. ; Jain, Ashok ; Corry, Robert J. ; Fung, John J. ; McCauley, Jerry ; Johnston, James ; Shapiro, Ron</creator><creatorcontrib>Shullo, Michael A. ; Rose, Meredith L. ; Vivas, Carlos ; Jordan, Mark L. ; Scantlebury, Velma P. ; Jain, Ashok ; Corry, Robert J. ; Fung, John J. ; McCauley, Jerry ; Johnston, James ; Shapiro, Ron</creatorcontrib><description>Study Objective. To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney‐pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin.
Design. Retrospective chart review.
Setting. University‐based tertiary care center.
Patients. Thirteen patients who had received enoxaparin within 10 days of kidney or kidney‐pancreas transplantation.
Intervention. Medical records were reviewed, and data from patients who had received low‐dose aspirin 81 mg once/day and enoxaparin within 10 days of transplantation were collected.
Measurements and Main Results. Major bleeding events were defined as intracranial or retroperitoneal bleeding, or a decrease in hemoglobin of greater than 2 g/dl that was confirmed on repeat evaluation. Nine (69%) of the 13 patients had confirmed major bleeding events and required blood transfusions. Six of the nine patients had elevated serum creatinine levels.
Conclusion. The combination of enoxaparin and low‐dose aspirin early after kidney or kidney‐pancreas transplantation was associated with a high frequency of hemorrhagic events. Further evaluation is needed to determine the safety of enoxaparin in combination with aspirin after transplantation.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1592/phco.22.3.184.33541</identifier><identifier>PMID: 11837557</identifier><identifier>CODEN: PHPYDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Anticoagulants - adverse effects ; Anticoagulants - therapeutic use ; Aspirin - adverse effects ; Aspirin - therapeutic use ; Biological and medical sciences ; Drug Therapy, Combination ; Drug toxicity and drugs side effects treatment ; Enoxaparin - adverse effects ; Enoxaparin - therapeutic use ; Female ; Fibrinolytic Agents - adverse effects ; Fibrinolytic Agents - therapeutic use ; Hemoglobins - analysis ; Humans ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; Pancreas Transplantation ; Pharmacology. Drug treatments ; Postoperative Hemorrhage - chemically induced ; Retrospective Studies ; Toxicity: blood</subject><ispartof>Pharmacotherapy, 2002-02, Vol.22 (2), p.184-187</ispartof><rights>2002 Pharmacotherapy Publications Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4507-15584aaff879e43e42cef020d2bf1a603b9c94258d7051001d8aff3d062f12703</citedby><cites>FETCH-LOGICAL-c4507-15584aaff879e43e42cef020d2bf1a603b9c94258d7051001d8aff3d062f12703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1592%2Fphco.22.3.184.33541$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1592%2Fphco.22.3.184.33541$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13469977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11837557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shullo, Michael A.</creatorcontrib><creatorcontrib>Rose, Meredith L.</creatorcontrib><creatorcontrib>Vivas, Carlos</creatorcontrib><creatorcontrib>Jordan, Mark L.</creatorcontrib><creatorcontrib>Scantlebury, Velma P.</creatorcontrib><creatorcontrib>Jain, Ashok</creatorcontrib><creatorcontrib>Corry, Robert J.</creatorcontrib><creatorcontrib>Fung, John J.</creatorcontrib><creatorcontrib>McCauley, Jerry</creatorcontrib><creatorcontrib>Johnston, James</creatorcontrib><creatorcontrib>Shapiro, Ron</creatorcontrib><title>Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>Study Objective. To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney‐pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin.
Design. Retrospective chart review.
Setting. University‐based tertiary care center.
Patients. Thirteen patients who had received enoxaparin within 10 days of kidney or kidney‐pancreas transplantation.
Intervention. Medical records were reviewed, and data from patients who had received low‐dose aspirin 81 mg once/day and enoxaparin within 10 days of transplantation were collected.
Measurements and Main Results. Major bleeding events were defined as intracranial or retroperitoneal bleeding, or a decrease in hemoglobin of greater than 2 g/dl that was confirmed on repeat evaluation. Nine (69%) of the 13 patients had confirmed major bleeding events and required blood transfusions. Six of the nine patients had elevated serum creatinine levels.
Conclusion. The combination of enoxaparin and low‐dose aspirin early after kidney or kidney‐pancreas transplantation was associated with a high frequency of hemorrhagic events. Further evaluation is needed to determine the safety of enoxaparin in combination with aspirin after transplantation.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticoagulants - adverse effects</subject><subject>Anticoagulants - therapeutic use</subject><subject>Aspirin - adverse effects</subject><subject>Aspirin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Enoxaparin - adverse effects</subject><subject>Enoxaparin - therapeutic use</subject><subject>Female</subject><subject>Fibrinolytic Agents - adverse effects</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreas Transplantation</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Hemorrhage - chemically induced</subject><subject>Retrospective Studies</subject><subject>Toxicity: blood</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9v0zAcQC0EYmXwCZBQLnBL8M9_4vhYdWNFTFBNQ0NcLNexqSGJg51q67fHoRW7IlmyZb9nWw-h14Ar4JK8H3cmVIRUtIKGVZRyBk_QAhrBSwnAnqIFJkKUGOPmDL1I6SfGBGpGnqMzgIYKzsUC3a1tH2Lc6R_eFKvQj503evJhSEVwxeUQHvSoox8KPbTFMo1-XuexyZAdplTc-2lXfPLtYA_FbdRDGjud91-iZ053yb46zefo64fL29W6vP5y9XG1vC4N41iUwHnDtHauEdIyahkx1mGCW7J1oGtMt9JIRnjTCswBY2ibDNMW18QBEZieo3fHe8cYfu9tmlTvk7Fd_oQN-6RyGgApIIP0CJoYUorWqTH6XseDAqzmnmruqQhRdJbU357ZenO6fr_tbfvonAJm4O0J0MnozuUCxqdHjrJaSjFz8sjd-84e_udttVkvbwitZ7c8uj5N9uGfq-MvlU8FV3efr5T8doO_X2xA1fQPu16fmw</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Shullo, Michael A.</creator><creator>Rose, Meredith L.</creator><creator>Vivas, Carlos</creator><creator>Jordan, Mark L.</creator><creator>Scantlebury, Velma P.</creator><creator>Jain, Ashok</creator><creator>Corry, Robert J.</creator><creator>Fung, John J.</creator><creator>McCauley, Jerry</creator><creator>Johnston, James</creator><creator>Shapiro, Ron</creator><general>Blackwell Publishing Ltd</general><general>Pharmacotherapy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200202</creationdate><title>Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants</title><author>Shullo, Michael A. ; Rose, Meredith L. ; Vivas, Carlos ; Jordan, Mark L. ; Scantlebury, Velma P. ; Jain, Ashok ; Corry, Robert J. ; Fung, John J. ; McCauley, Jerry ; Johnston, James ; Shapiro, Ron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-15584aaff879e43e42cef020d2bf1a603b9c94258d7051001d8aff3d062f12703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticoagulants - adverse effects</topic><topic>Anticoagulants - therapeutic use</topic><topic>Aspirin - adverse effects</topic><topic>Aspirin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Enoxaparin - adverse effects</topic><topic>Enoxaparin - therapeutic use</topic><topic>Female</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pancreas Transplantation</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Hemorrhage - chemically induced</topic><topic>Retrospective Studies</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shullo, Michael A.</creatorcontrib><creatorcontrib>Rose, Meredith L.</creatorcontrib><creatorcontrib>Vivas, Carlos</creatorcontrib><creatorcontrib>Jordan, Mark L.</creatorcontrib><creatorcontrib>Scantlebury, Velma P.</creatorcontrib><creatorcontrib>Jain, Ashok</creatorcontrib><creatorcontrib>Corry, Robert J.</creatorcontrib><creatorcontrib>Fung, John J.</creatorcontrib><creatorcontrib>McCauley, Jerry</creatorcontrib><creatorcontrib>Johnston, James</creatorcontrib><creatorcontrib>Shapiro, Ron</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shullo, Michael A.</au><au>Rose, Meredith L.</au><au>Vivas, Carlos</au><au>Jordan, Mark L.</au><au>Scantlebury, Velma P.</au><au>Jain, Ashok</au><au>Corry, Robert J.</au><au>Fung, John J.</au><au>McCauley, Jerry</au><au>Johnston, James</au><au>Shapiro, Ron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>2002-02</date><risdate>2002</risdate><volume>22</volume><issue>2</issue><spage>184</spage><epage>187</epage><pages>184-187</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><coden>PHPYDQ</coden><abstract>Study Objective. To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney‐pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin.
Design. Retrospective chart review.
Setting. University‐based tertiary care center.
Patients. Thirteen patients who had received enoxaparin within 10 days of kidney or kidney‐pancreas transplantation.
Intervention. Medical records were reviewed, and data from patients who had received low‐dose aspirin 81 mg once/day and enoxaparin within 10 days of transplantation were collected.
Measurements and Main Results. Major bleeding events were defined as intracranial or retroperitoneal bleeding, or a decrease in hemoglobin of greater than 2 g/dl that was confirmed on repeat evaluation. Nine (69%) of the 13 patients had confirmed major bleeding events and required blood transfusions. Six of the nine patients had elevated serum creatinine levels.
Conclusion. The combination of enoxaparin and low‐dose aspirin early after kidney or kidney‐pancreas transplantation was associated with a high frequency of hemorrhagic events. Further evaluation is needed to determine the safety of enoxaparin in combination with aspirin after transplantation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11837557</pmid><doi>10.1592/phco.22.3.184.33541</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pharmacotherapy, 2002-02, Vol.22 (2), p.184-187 |
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| subjects | Adult Aged Anticoagulants - adverse effects Anticoagulants - therapeutic use Aspirin - adverse effects Aspirin - therapeutic use Biological and medical sciences Drug Therapy, Combination Drug toxicity and drugs side effects treatment Enoxaparin - adverse effects Enoxaparin - therapeutic use Female Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemoglobins - analysis Humans Kidney Transplantation Male Medical sciences Middle Aged Pancreas Transplantation Pharmacology. Drug treatments Postoperative Hemorrhage - chemically induced Retrospective Studies Toxicity: blood |
| title | Hemorrhagic Complications of Enoxaparin and Aspirin in Patients with Kidney Transplants |
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