Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson’s Disease
Parkinson’s disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MR...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2017-06, Vol.16 (3), p.623-628 |
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| creator | Piccinin, Camila Callegari Campos, Lidiane Soares Guimarães, Rachel Paes Piovesana, Luiza Gonzaga dos Santos, Maria Cristina Arci Azevedo, Paula Christina Campos, Brunno Machado de Rezende, Thiago Junqueira Ribeiro Amato-Filho, Augusto Cendes, Fernando D’Abreu, Anelyssa |
| description | Parkinson’s disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR. For a precise evaluation of the cerebellum, we used the SUIT tool for voxel-based morphometry. Applying
p =
0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (
p <
0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor. |
| doi_str_mv | 10.1007/s12311-016-0834-5 |
| format | Article |
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p =
0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (
p <
0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor.</description><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-016-0834-5</identifier><identifier>PMID: 27853938</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Analysis of covariance ; Atrophy ; Basal ganglia ; Biomedical and Life Sciences ; Biomedicine ; Brain Mapping ; Cerebellar Diseases - pathology ; Cerebellum ; Cerebellum - pathology ; Cortex ; Female ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Morphometry ; Movement disorders ; Neural Pathways - pathology ; Neural Pathways - physiopathology ; Neurobiology ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Original Paper ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Substantia grisea ; Tremor ; Tremor - pathology ; Tremor - physiopathology</subject><ispartof>Cerebellum (London, England), 2017-06, Vol.16 (3), p.623-628</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>The Cerebellum is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-23bc8660d34022ded605ccf0251aaf8d2f40b222d86421602b8100f8e6ffdeaf3</citedby><cites>FETCH-LOGICAL-c508t-23bc8660d34022ded605ccf0251aaf8d2f40b222d86421602b8100f8e6ffdeaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-016-0834-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-016-0834-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27853938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piccinin, Camila Callegari</creatorcontrib><creatorcontrib>Campos, Lidiane Soares</creatorcontrib><creatorcontrib>Guimarães, Rachel Paes</creatorcontrib><creatorcontrib>Piovesana, Luiza Gonzaga</creatorcontrib><creatorcontrib>dos Santos, Maria Cristina Arci</creatorcontrib><creatorcontrib>Azevedo, Paula Christina</creatorcontrib><creatorcontrib>Campos, Brunno Machado</creatorcontrib><creatorcontrib>de Rezende, Thiago Junqueira Ribeiro</creatorcontrib><creatorcontrib>Amato-Filho, Augusto</creatorcontrib><creatorcontrib>Cendes, Fernando</creatorcontrib><creatorcontrib>D’Abreu, Anelyssa</creatorcontrib><title>Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson’s Disease</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>Parkinson’s disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR. For a precise evaluation of the cerebellum, we used the SUIT tool for voxel-based morphometry. Applying
p =
0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (
p <
0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of covariance</subject><subject>Atrophy</subject><subject>Basal ganglia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Mapping</subject><subject>Cerebellar Diseases - pathology</subject><subject>Cerebellum</subject><subject>Cerebellum - pathology</subject><subject>Cortex</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphometry</subject><subject>Movement disorders</subject><subject>Neural Pathways - pathology</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurobiology</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Substantia grisea</subject><subject>Tremor</subject><subject>Tremor - pathology</subject><subject>Tremor - physiopathology</subject><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1uEzEQxy1URD_gAXpBlnrhsu3Y3vU6xygFWqkSESpny7sety5ZO9iO1Nx4DV6PJ8FRSgVInDzy_OY_H39CThmcM4D-IjMuGGuAyQaUaJvuBTlibS-algs4eI45PyTHOT8AcA5t_4oc8l51YibUEXm89M5hwlC8WdGlKQVToNHRRf0ccLUyic5Liuv7LfWB3iacYmqWCW2cfDChUBMsnX_1AYsfLz77O2992f5FLE2q-RzDz-8_Mr30GU3G1-SlM6uMb57eE_Llw_vbxVVz8-nj9WJ-04wdqNJwMYxKSrCirdNbtBK6cXTAO2aMU5a7Foa6oVWy5UwCH1Q9jVMonbNonDgh7_a66xS_bTAXPfk87hYLGDdZM9UyJlQHsqJn_6APcZNCna5Ss1lfUSkqxfbUmGLOCZ1eJz-ZtNUM9M4WvbdFV1v0zhbd1Zq3T8qbYUL7XPHbhwrwPZBrKtxh-qP1f1V_Ae5imbU</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Piccinin, Camila Callegari</creator><creator>Campos, Lidiane Soares</creator><creator>Guimarães, Rachel Paes</creator><creator>Piovesana, Luiza Gonzaga</creator><creator>dos Santos, Maria Cristina Arci</creator><creator>Azevedo, Paula Christina</creator><creator>Campos, Brunno Machado</creator><creator>de Rezende, Thiago Junqueira Ribeiro</creator><creator>Amato-Filho, Augusto</creator><creator>Cendes, Fernando</creator><creator>D’Abreu, Anelyssa</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson’s Disease</title><author>Piccinin, Camila Callegari ; Campos, Lidiane Soares ; Guimarães, Rachel Paes ; Piovesana, Luiza Gonzaga ; dos Santos, Maria Cristina Arci ; Azevedo, Paula Christina ; Campos, Brunno Machado ; de Rezende, Thiago Junqueira Ribeiro ; Amato-Filho, Augusto ; Cendes, Fernando ; D’Abreu, Anelyssa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-23bc8660d34022ded605ccf0251aaf8d2f40b222d86421602b8100f8e6ffdeaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of covariance</topic><topic>Atrophy</topic><topic>Basal ganglia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Mapping</topic><topic>Cerebellar Diseases - pathology</topic><topic>Cerebellum</topic><topic>Cerebellum - pathology</topic><topic>Cortex</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morphometry</topic><topic>Movement disorders</topic><topic>Neural Pathways - pathology</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurobiology</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Substantia grisea</topic><topic>Tremor</topic><topic>Tremor - pathology</topic><topic>Tremor - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piccinin, Camila Callegari</creatorcontrib><creatorcontrib>Campos, Lidiane Soares</creatorcontrib><creatorcontrib>Guimarães, Rachel Paes</creatorcontrib><creatorcontrib>Piovesana, Luiza Gonzaga</creatorcontrib><creatorcontrib>dos Santos, Maria Cristina Arci</creatorcontrib><creatorcontrib>Azevedo, Paula Christina</creatorcontrib><creatorcontrib>Campos, Brunno Machado</creatorcontrib><creatorcontrib>de Rezende, Thiago Junqueira Ribeiro</creatorcontrib><creatorcontrib>Amato-Filho, Augusto</creatorcontrib><creatorcontrib>Cendes, Fernando</creatorcontrib><creatorcontrib>D’Abreu, Anelyssa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebellum (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piccinin, Camila Callegari</au><au>Campos, Lidiane Soares</au><au>Guimarães, Rachel Paes</au><au>Piovesana, Luiza Gonzaga</au><au>dos Santos, Maria Cristina Arci</au><au>Azevedo, Paula Christina</au><au>Campos, Brunno Machado</au><au>de Rezende, Thiago Junqueira Ribeiro</au><au>Amato-Filho, Augusto</au><au>Cendes, Fernando</au><au>D’Abreu, Anelyssa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson’s Disease</atitle><jtitle>Cerebellum (London, England)</jtitle><stitle>Cerebellum</stitle><addtitle>Cerebellum</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>16</volume><issue>3</issue><spage>623</spage><epage>628</epage><pages>623-628</pages><issn>1473-4222</issn><eissn>1473-4230</eissn><abstract>Parkinson’s disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR. For a precise evaluation of the cerebellum, we used the SUIT tool for voxel-based morphometry. Applying
p =
0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (
p <
0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27853938</pmid><doi>10.1007/s12311-016-0834-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Analysis of covariance Atrophy Basal ganglia Biomedical and Life Sciences Biomedicine Brain Mapping Cerebellar Diseases - pathology Cerebellum Cerebellum - pathology Cortex Female Humans Image Processing, Computer-Assisted - methods Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Morphometry Movement disorders Neural Pathways - pathology Neural Pathways - physiopathology Neurobiology Neurodegenerative diseases Neurology Neurosciences Original Paper Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Substantia grisea Tremor Tremor - pathology Tremor - physiopathology |
| title | Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson’s Disease |
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