Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks

The normal adult human mammary gland is a continuous bilayered epithelial system. Bipotent and myoepithelial progenitors are prominent and unique components of the outer (basal) layer. The inner (luminal) layer includes both luminal-restricted progenitors and a phenotypically separable fraction that...

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Veröffentlicht in:	Cell reports (Cambridge) 2016-11, Vol.17 (8), p.2060-2074
Hauptverfasser:	Pellacani, Davide, Bilenky, Misha, Kannan, Nagarajan, Heravi-Moussavi, Alireza, Knapp, David J.H.F., Gakkhar, Sitanshu, Moksa, Michelle, Carles, Annaick, Moore, Richard, Mungall, Andrew J., Marra, Marco A., Jones, Steven J.M., Aparicio, Samuel, Hirst, Martin, Eaves, Connie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Breast - metabolism Cell Separation chromatin Chromatin - metabolism enhancer Enhancer Elements, Genetic - genetics Epigenesis, Genetic epigenomic Epithelial Cells - cytology Epithelial Cells - metabolism Female Gene Regulatory Networks Humans mammary cells normal human breast Phenotype profiling Promoter Regions, Genetic regulatory network Reproducibility of Results stem cells transcription factors Transcription Factors - metabolism transcriptome
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