Metabotropic glutamate receptor 5 as a potential target for smoking cessation

Rationale Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as varenicline, that target the nicotinic receptor. Rela...

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Veröffentlicht in:	Psychopharmacology 2017-05, Vol.234 (9-10), p.1357-1370
Hauptverfasser:	Chiamulera, Cristiano, Marzo, Claudio Marcello, Balfour, David J. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Addictive - drug therapy Behavior, Addictive - metabolism Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Dependence Drug Delivery Systems - methods Drug therapy Excitatory Amino Acid Antagonists - administration & dosage Health aspects Humans Metabotropic glutamate receptors Methods Neurosciences Nicotine Nicotinic Agonists - administration & dosage Pharmacological research Pharmacology/Toxicology Physiological aspects Psychiatry Psychopharmacology Receptor, Metabotropic Glutamate 5 - agonists Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors Receptor, Metabotropic Glutamate 5 - metabolism Receptors, Nicotinic - metabolism Review Self Administration Smoking - drug therapy Smoking - metabolism Smoking cessation Smoking Cessation - methods Tobacco habit Tobacco smoke Tobacco Use Disorder - drug therapy Tobacco Use Disorder - metabolism
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