Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy

Background Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundr...

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Veröffentlicht in:Journal of gastroenterology 2017-08, Vol.52 (8), p.879-888
Hauptverfasser: Takenaka, Kento, Ohtsuka, Kazuo, Kitazume, Yoshio, Matsuoka, Katsuyoshi, Fujii, Toshimitsu, Nagahori, Masakazu, Kimura, Maiko, Fujioka, Tomoyuki, Araki, Akihiro, Watanabe, Mamoru
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container_issue 8
container_start_page 879
container_title Journal of gastroenterology
container_volume 52
creator Takenaka, Kento
Ohtsuka, Kazuo
Kitazume, Yoshio
Matsuoka, Katsuyoshi
Fujii, Toshimitsu
Nagahori, Masakazu
Kimura, Maiko
Fujioka, Tomoyuki
Araki, Akihiro
Watanabe, Mamoru
description Background Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated. Results The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging ( P  = 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery ( P  = 0.002 at 6 months and P  
doi_str_mv 10.1007/s00535-016-1284-z
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We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated. Results The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging ( P  = 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery ( P  = 0.002 at 6 months and P  &lt; 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year ( P  = 0.001). Conclusions The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. But MR-negative–BAE-positive strictures were also associated with an increased risk compared with no strictures after 1 year of follow-up.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-016-1284-z</identifier><identifier>PMID: 27848026</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adolescent ; Adult ; Aged ; Balloon Enteroscopy ; Balloon treatment ; Colorectal Surgery ; Comparative analysis ; Constriction, Pathologic - diagnostic imaging ; Constriction, Pathologic - etiology ; Constriction, Pathologic - surgery ; Crohn Disease - complications ; Crohn Disease - diagnostic imaging ; Crohn Disease - surgery ; Crohn's disease ; False Negative Reactions ; Female ; Fistulae ; Gastroenterology ; Hepatology ; Humans ; Intestinal Obstruction - diagnostic imaging ; Intestinal Obstruction - etiology ; Intestinal Obstruction - surgery ; Intestine, Small - diagnostic imaging ; Intestine, Small - pathology ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine ; Medicine &amp; Public Health ; Medicine, Experimental ; Middle Aged ; Multiple regression analysis ; Original Article—Alimentary Tract ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Small intestine ; Stricture ; Surgery ; Surgical Oncology ; Young Adult</subject><ispartof>Journal of gastroenterology, 2017-08, Vol.52 (8), p.879-888</ispartof><rights>Japanese Society of Gastroenterology 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</citedby><cites>FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-016-1284-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-016-1284-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27848026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenaka, Kento</creatorcontrib><creatorcontrib>Ohtsuka, Kazuo</creatorcontrib><creatorcontrib>Kitazume, Yoshio</creatorcontrib><creatorcontrib>Matsuoka, Katsuyoshi</creatorcontrib><creatorcontrib>Fujii, Toshimitsu</creatorcontrib><creatorcontrib>Nagahori, Masakazu</creatorcontrib><creatorcontrib>Kimura, Maiko</creatorcontrib><creatorcontrib>Fujioka, Tomoyuki</creatorcontrib><creatorcontrib>Araki, Akihiro</creatorcontrib><creatorcontrib>Watanabe, Mamoru</creatorcontrib><title>Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated. Results The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging ( P  = 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery ( P  = 0.002 at 6 months and P  &lt; 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year ( P  = 0.001). Conclusions The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. 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Ohtsuka, Kazuo ; Kitazume, Yoshio ; Matsuoka, Katsuyoshi ; Fujii, Toshimitsu ; Nagahori, Masakazu ; Kimura, Maiko ; Fujioka, Tomoyuki ; Araki, Akihiro ; Watanabe, Mamoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Balloon Enteroscopy</topic><topic>Balloon treatment</topic><topic>Colorectal Surgery</topic><topic>Comparative analysis</topic><topic>Constriction, Pathologic - diagnostic imaging</topic><topic>Constriction, Pathologic - etiology</topic><topic>Constriction, Pathologic - surgery</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - diagnostic imaging</topic><topic>Crohn Disease - surgery</topic><topic>Crohn's disease</topic><topic>False Negative Reactions</topic><topic>Female</topic><topic>Fistulae</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Intestinal Obstruction - diagnostic imaging</topic><topic>Intestinal Obstruction - etiology</topic><topic>Intestinal Obstruction - surgery</topic><topic>Intestine, Small - diagnostic imaging</topic><topic>Intestine, Small - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine &amp; 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We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated. Results The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging ( P  = 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery ( P  = 0.002 at 6 months and P  &lt; 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year ( P  = 0.001). Conclusions The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. But MR-negative–BAE-positive strictures were also associated with an increased risk compared with no strictures after 1 year of follow-up.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27848026</pmid><doi>10.1007/s00535-016-1284-z</doi><tpages>10</tpages></addata></record>
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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Abdominal Surgery
Adolescent
Adult
Aged
Balloon Enteroscopy
Balloon treatment
Colorectal Surgery
Comparative analysis
Constriction, Pathologic - diagnostic imaging
Constriction, Pathologic - etiology
Constriction, Pathologic - surgery
Crohn Disease - complications
Crohn Disease - diagnostic imaging
Crohn Disease - surgery
Crohn's disease
False Negative Reactions
Female
Fistulae
Gastroenterology
Hepatology
Humans
Intestinal Obstruction - diagnostic imaging
Intestinal Obstruction - etiology
Intestinal Obstruction - surgery
Intestine, Small - diagnostic imaging
Intestine, Small - pathology
Magnetic Resonance Imaging
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Multiple regression analysis
Original Article—Alimentary Tract
Predictive Value of Tests
Prospective Studies
Risk Factors
Small intestine
Stricture
Surgery
Surgical Oncology
Young Adult
title Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy
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