Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy
Background Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. Methods Two hundr...
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creator | Takenaka, Kento Ohtsuka, Kazuo Kitazume, Yoshio Matsuoka, Katsuyoshi Fujii, Toshimitsu Nagahori, Masakazu Kimura, Maiko Fujioka, Tomoyuki Araki, Akihiro Watanabe, Mamoru |
description | Background
Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference.
Methods
Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated.
Results
The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging (
P
= 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery (
P
= 0.002 at 6 months and
P
|
doi_str_mv | 10.1007/s00535-016-1284-z |
format | Article |
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Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference.
Methods
Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated.
Results
The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging (
P
= 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery (
P
= 0.002 at 6 months and
P
< 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year (
P
= 0.001).
Conclusions
The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. But MR-negative–BAE-positive strictures were also associated with an increased risk compared with no strictures after 1 year of follow-up.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-016-1284-z</identifier><identifier>PMID: 27848026</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adolescent ; Adult ; Aged ; Balloon Enteroscopy ; Balloon treatment ; Colorectal Surgery ; Comparative analysis ; Constriction, Pathologic - diagnostic imaging ; Constriction, Pathologic - etiology ; Constriction, Pathologic - surgery ; Crohn Disease - complications ; Crohn Disease - diagnostic imaging ; Crohn Disease - surgery ; Crohn's disease ; False Negative Reactions ; Female ; Fistulae ; Gastroenterology ; Hepatology ; Humans ; Intestinal Obstruction - diagnostic imaging ; Intestinal Obstruction - etiology ; Intestinal Obstruction - surgery ; Intestine, Small - diagnostic imaging ; Intestine, Small - pathology ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Multiple regression analysis ; Original Article—Alimentary Tract ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Small intestine ; Stricture ; Surgery ; Surgical Oncology ; Young Adult</subject><ispartof>Journal of gastroenterology, 2017-08, Vol.52 (8), p.879-888</ispartof><rights>Japanese Society of Gastroenterology 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</citedby><cites>FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-016-1284-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-016-1284-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27848026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenaka, Kento</creatorcontrib><creatorcontrib>Ohtsuka, Kazuo</creatorcontrib><creatorcontrib>Kitazume, Yoshio</creatorcontrib><creatorcontrib>Matsuoka, Katsuyoshi</creatorcontrib><creatorcontrib>Fujii, Toshimitsu</creatorcontrib><creatorcontrib>Nagahori, Masakazu</creatorcontrib><creatorcontrib>Kimura, Maiko</creatorcontrib><creatorcontrib>Fujioka, Tomoyuki</creatorcontrib><creatorcontrib>Araki, Akihiro</creatorcontrib><creatorcontrib>Watanabe, Mamoru</creatorcontrib><title>Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference.
Methods
Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated.
Results
The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging (
P
= 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery (
P
= 0.002 at 6 months and
P
< 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year (
P
= 0.001).
Conclusions
The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. But MR-negative–BAE-positive strictures were also associated with an increased risk compared with no strictures after 1 year of follow-up.</description><subject>Abdominal Surgery</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Balloon Enteroscopy</subject><subject>Balloon treatment</subject><subject>Colorectal Surgery</subject><subject>Comparative analysis</subject><subject>Constriction, Pathologic - diagnostic imaging</subject><subject>Constriction, Pathologic - etiology</subject><subject>Constriction, Pathologic - surgery</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - diagnostic imaging</subject><subject>Crohn Disease - surgery</subject><subject>Crohn's disease</subject><subject>False Negative Reactions</subject><subject>Female</subject><subject>Fistulae</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Intestinal Obstruction - diagnostic imaging</subject><subject>Intestinal Obstruction - etiology</subject><subject>Intestinal Obstruction - surgery</subject><subject>Intestine, Small - diagnostic imaging</subject><subject>Intestine, Small - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multiple regression analysis</subject><subject>Original Article—Alimentary Tract</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Small intestine</subject><subject>Stricture</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Young Adult</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctu3CAUhlHVqJmmfYBuKqRuunEKmIvpLhr1JqXKJl0jjI8nRDZMATdKVn2Nvl6eJIwmvaoREojD9_86nB-hF5QcU0LUm0yIaEVDqGwo63hz8witKK8VoRl7jFZEc95QqvgheprzJSG0JaJ7gg6Z6nhHmFyh9NluAhTvcIIcgw0OMHyz02KLjwGPMeE822nCfbyCCeeSvCtLZbEPeJ3iRbj9_iPjwWewGd5iF-etTb5a4StfLnBftbFeIBRIMbu4vX6GDkY7ZXh-fx6hL-_fna8_NqdnHz6tT04bx2Vb6q6EdqCcHiWRkimmoJcDc0QpaBWIjgMQMYJ2PbHc0Y4SbjkHJnQ76LE9Qq_3vtsUvy6Qi5l9djBNNkBcsqEdp3UghOmKvvoHvYxLCrU7QzWtw2SS0d_Uxk5gfBhjSdbtTM2Jolx0rVQ7r-P_UHUNMHsXA4y-1v8S0L3A1QHlBKPZJj_bdG0oMbuczT5nU3M2u5zNTdW8vG946WcYfil-BlsBtgdyfQobSH_86EHXO86atCM</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Takenaka, Kento</creator><creator>Ohtsuka, Kazuo</creator><creator>Kitazume, Yoshio</creator><creator>Matsuoka, Katsuyoshi</creator><creator>Fujii, Toshimitsu</creator><creator>Nagahori, Masakazu</creator><creator>Kimura, Maiko</creator><creator>Fujioka, Tomoyuki</creator><creator>Araki, Akihiro</creator><creator>Watanabe, Mamoru</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy</title><author>Takenaka, Kento ; Ohtsuka, Kazuo ; Kitazume, Yoshio ; Matsuoka, Katsuyoshi ; Fujii, Toshimitsu ; Nagahori, Masakazu ; Kimura, Maiko ; Fujioka, Tomoyuki ; Araki, Akihiro ; Watanabe, Mamoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-c4759ce7c9f60662727eb6d2c077e37e584ee05fe9cb0a4c18104a44e2593d9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Balloon Enteroscopy</topic><topic>Balloon treatment</topic><topic>Colorectal Surgery</topic><topic>Comparative analysis</topic><topic>Constriction, Pathologic - diagnostic imaging</topic><topic>Constriction, Pathologic - etiology</topic><topic>Constriction, Pathologic - surgery</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - diagnostic imaging</topic><topic>Crohn Disease - surgery</topic><topic>Crohn's disease</topic><topic>False Negative Reactions</topic><topic>Female</topic><topic>Fistulae</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Intestinal Obstruction - diagnostic imaging</topic><topic>Intestinal Obstruction - etiology</topic><topic>Intestinal Obstruction - surgery</topic><topic>Intestine, Small - diagnostic imaging</topic><topic>Intestine, Small - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multiple regression analysis</topic><topic>Original Article—Alimentary Tract</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Small intestine</topic><topic>Stricture</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenaka, Kento</creatorcontrib><creatorcontrib>Ohtsuka, Kazuo</creatorcontrib><creatorcontrib>Kitazume, Yoshio</creatorcontrib><creatorcontrib>Matsuoka, Katsuyoshi</creatorcontrib><creatorcontrib>Fujii, Toshimitsu</creatorcontrib><creatorcontrib>Nagahori, Masakazu</creatorcontrib><creatorcontrib>Kimura, Maiko</creatorcontrib><creatorcontrib>Fujioka, Tomoyuki</creatorcontrib><creatorcontrib>Araki, Akihiro</creatorcontrib><creatorcontrib>Watanabe, Mamoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenaka, Kento</au><au>Ohtsuka, Kazuo</au><au>Kitazume, Yoshio</au><au>Matsuoka, Katsuyoshi</au><au>Fujii, Toshimitsu</au><au>Nagahori, Masakazu</au><au>Kimura, Maiko</au><au>Fujioka, Tomoyuki</au><au>Araki, Akihiro</au><au>Watanabe, Mamoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>52</volume><issue>8</issue><spage>879</spage><epage>888</epage><pages>879-888</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference.
Methods
Two hundred Crohn’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated.
Results
The accuracy of MR imaging for detection of small bowel strictures was defined by a sensitivity of 60.6% and a specificity of 93.4%. Major strictures (diameter less than 10 mm or with internal fistula), long strictures (length 10 mm or greater), and prestenotic dilatation were predictors of stricture detection by MR imaging (
P
= 0.001, 0.017, and 0.002 respectively). Surgery was performed in 31.6% of patients (18 of 57) in the MR-positive–BAE-positive stricture group and in 10.8% of patients (4 of 37) in the MR-negative–BAE-positive stricture group. Multiple regression analysis showed MR-positive–BAE-positive strictures were an independent risk factor for surgery (
P
= 0.002 at 6 months and
P
< 0.001 at 1 year). The surgery-free rate in the MR-negative–BAE-positive stricture group was significantly lower than that in nonstricture group at 1 year (
P
= 0.001).
Conclusions
The specificity of MR imaging for detection of small bowel strictures was clinically sufficient, and the MR procedure could detect critical strictures, which was a predictive factor for surgery. But MR-negative–BAE-positive strictures were also associated with an increased risk compared with no strictures after 1 year of follow-up.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27848026</pmid><doi>10.1007/s00535-016-1284-z</doi><tpages>10</tpages></addata></record> |
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subjects | Abdominal Surgery Adolescent Adult Aged Balloon Enteroscopy Balloon treatment Colorectal Surgery Comparative analysis Constriction, Pathologic - diagnostic imaging Constriction, Pathologic - etiology Constriction, Pathologic - surgery Crohn Disease - complications Crohn Disease - diagnostic imaging Crohn Disease - surgery Crohn's disease False Negative Reactions Female Fistulae Gastroenterology Hepatology Humans Intestinal Obstruction - diagnostic imaging Intestinal Obstruction - etiology Intestinal Obstruction - surgery Intestine, Small - diagnostic imaging Intestine, Small - pathology Magnetic Resonance Imaging Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Multiple regression analysis Original Article—Alimentary Tract Predictive Value of Tests Prospective Studies Risk Factors Small intestine Stricture Surgery Surgical Oncology Young Adult |
title | Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy |
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