Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells

Ribosome-inactivating proteins (RIPs) remove a specific adenine from 28S rRNA leading to inactivation of ribosomes and arrest of translation. Great interest as to a possible second physiological substrate for RIPs came from the observation that in vitro RIPs remove adenine from DNA. This paper addre...

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Veröffentlicht in:	The FASEB journal 2002-03, Vol.16 (3), p.365-372
Hauptverfasser:	Brigotti, Maurizio, Alfieri, Roberta, Sestili, Piero, Bonelli, Mara, Petronini, Pier Giorgio, Guidarelli, Andrea, Barbieri, Luigi, Stirpe, Fiorenzo, Sperti, Simonetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - metabolism Apoptosis Caspase 3 Caspases - metabolism Cell Nucleus - drug effects Cell Nucleus - ultrastructure Cells, Cultured Chromatin - metabolism DNA Damage DNA Fragmentation Endothelium - drug effects Endothelium - enzymology Endothelium - ultrastructure Humans Kinetics Microscopy, Fluorescence N-Glycosyl Hydrolases - metabolism Protein Biosynthesis - drug effects Ricin - toxicity Shiga Toxin 1 - toxicity
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