Prevalence, genotype distribution and outcome of hepatitis C infections among the employees of the Hungarian Central Hospital for Infectious Diseases
Blood samples from 477 hospital workers (HWs) at the Central Hospital for Infectious Diseases, Budapest, Hungary were tested for hepatitis C virus (HCV) antibodies by enzyme immunoassay (EIA), and 13 (2.7%) of these were found to be HCV antibody positive. Ten (2.7%) were from nursing/housekeeping st...
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| Veröffentlicht in: | The Journal of hospital infection 2001-12, Vol.49 (4), p.239-244 |
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| container_title | The Journal of hospital infection |
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| creator | Mihály, I. Telegdy, L. Ibrányi, E. Lukács, A. Rókusz, L. Bánkuti, É. Dóczy, J. |
| description | Blood samples from 477 hospital workers (HWs) at the Central Hospital for Infectious Diseases, Budapest, Hungary were tested for hepatitis C virus (HCV) antibodies by enzyme immunoassay (EIA), and 13 (2.7%) of these were found to be HCV antibody positive. Ten (2.7%) were from nursing/housekeeping staff and three (2.9%) from medical staff. HCV antibody positive HWs were detected in 10 of 17 work places, and the prevalence rates in these departments or units varied between 1.2% and 6.5%. The prevalence increased gradually with increasing age, being 0% in these under 21 years of age and 9.5% in those above 50 years of age. Eleven (85%) of 13 HCV antibody positive HWs had HCV RNA in their sera, four of them intermittently during the follow-up period. HCV genotype 1 was present in two HWs, 1b in six HWs, 3a in one HW and 4 in two HWs. Chronic hepatitis C has developed in six (46%) HCV antibody positive HWs. Although the source of infection through needlestick could only be traced directly in one case, circumstantial evidence indicated that the majority of infections were occupationally acquired, originating from percutaneous or mucocutaneous exposure. |
| doi_str_mv | 10.1053/jhin.2001.1087 |
| format | Article |
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Ten (2.7%) were from nursing/housekeeping staff and three (2.9%) from medical staff. HCV antibody positive HWs were detected in 10 of 17 work places, and the prevalence rates in these departments or units varied between 1.2% and 6.5%. The prevalence increased gradually with increasing age, being 0% in these under 21 years of age and 9.5% in those above 50 years of age. Eleven (85%) of 13 HCV antibody positive HWs had HCV RNA in their sera, four of them intermittently during the follow-up period. HCV genotype 1 was present in two HWs, 1b in six HWs, 3a in one HW and 4 in two HWs. Chronic hepatitis C has developed in six (46%) HCV antibody positive HWs. 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Ten (2.7%) were from nursing/housekeeping staff and three (2.9%) from medical staff. HCV antibody positive HWs were detected in 10 of 17 work places, and the prevalence rates in these departments or units varied between 1.2% and 6.5%. The prevalence increased gradually with increasing age, being 0% in these under 21 years of age and 9.5% in those above 50 years of age. Eleven (85%) of 13 HCV antibody positive HWs had HCV RNA in their sera, four of them intermittently during the follow-up period. HCV genotype 1 was present in two HWs, 1b in six HWs, 3a in one HW and 4 in two HWs. Chronic hepatitis C has developed in six (46%) HCV antibody positive HWs. Although the source of infection through needlestick could only be traced directly in one case, circumstantial evidence indicated that the majority of infections were occupationally acquired, originating from percutaneous or mucocutaneous exposure.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Genome, Human</subject><subject>Health Status</subject><subject>Hepatitis C</subject><subject>Hepatitis C Antibodies - blood</subject><subject>hepatitis C genotypes</subject><subject>Hepatitis C, Chronic - epidemiology</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Immunoenzyme Techniques</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>occupational hazard</subject><subject>Personnel, Hospital</subject><subject>Prevalence</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2P0zAQhi0EYruFK0fkC5w2xeN8H1H56EorwQHOlutMWq8SO3iclfpD-L84aqQ9cbDsGT1-NfO-jL0DsQNR5p8ez9btpBCQyqZ-wTZQ5jKTbd6-ZBsBbZlVtYAbdkv0KIRI_fI1uwGoi4SLDfv7M-CTHtAZvOMndD5eJuSdpRjscY7WO65dx_0cjR-R-56fcdLRRkt8z63r0SwQcT16d-LxjBzHafAXRFropXGY3UkHqx3fo4tBD_zgabIxPXof-P0qMhP_Ygk1Ib1hr3o9EL5d7y37_e3rr_0he_jx_X7_-SEzhYCYgWnbpqhAy7otGyNrWVZpMykBGl1J3Yu2KnKJ0PW6NFgei6apclElW9q-Asi37ONVdwr-z4wU1WjJ4DBoh2keBU0h8jydLdtdQRM8UcBeTcGOOlwUCLUEoZYg1BKEWoJIH96vyvNxxO4ZX51PwIcV0GT00AftjKVnLi9KAXWbuObKYfLhyWJQZOwSV2dDsk113v5vhn-3gaV8</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Mihály, I.</creator><creator>Telegdy, L.</creator><creator>Ibrányi, E.</creator><creator>Lukács, A.</creator><creator>Rókusz, L.</creator><creator>Bánkuti, É.</creator><creator>Dóczy, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20011201</creationdate><title>Prevalence, genotype distribution and outcome of hepatitis C infections among the employees of the Hungarian Central Hospital for Infectious Diseases</title><author>Mihály, I. ; Telegdy, L. ; Ibrányi, E. ; Lukács, A. ; Rókusz, L. ; Bánkuti, É. ; Dóczy, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-1c998461a27958c2725617422118a62af096432e1dfa5ce5b48863061959f6113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Genome, Human</topic><topic>Health Status</topic><topic>Hepatitis C</topic><topic>Hepatitis C Antibodies - blood</topic><topic>hepatitis C genotypes</topic><topic>Hepatitis C, Chronic - epidemiology</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hungary - epidemiology</topic><topic>Immunoenzyme Techniques</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Exposure</topic><topic>occupational hazard</topic><topic>Personnel, Hospital</topic><topic>Prevalence</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihály, I.</creatorcontrib><creatorcontrib>Telegdy, L.</creatorcontrib><creatorcontrib>Ibrányi, E.</creatorcontrib><creatorcontrib>Lukács, A.</creatorcontrib><creatorcontrib>Rókusz, L.</creatorcontrib><creatorcontrib>Bánkuti, É.</creatorcontrib><creatorcontrib>Dóczy, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of hospital infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihály, I.</au><au>Telegdy, L.</au><au>Ibrányi, E.</au><au>Lukács, A.</au><au>Rókusz, L.</au><au>Bánkuti, É.</au><au>Dóczy, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, genotype distribution and outcome of hepatitis C infections among the employees of the Hungarian Central Hospital for Infectious Diseases</atitle><jtitle>The Journal of hospital infection</jtitle><addtitle>J Hosp Infect</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>49</volume><issue>4</issue><spage>239</spage><epage>244</epage><pages>239-244</pages><issn>0195-6701</issn><eissn>1532-2939</eissn><abstract>Blood samples from 477 hospital workers (HWs) at the Central Hospital for Infectious Diseases, Budapest, Hungary were tested for hepatitis C virus (HCV) antibodies by enzyme immunoassay (EIA), and 13 (2.7%) of these were found to be HCV antibody positive. Ten (2.7%) were from nursing/housekeeping staff and three (2.9%) from medical staff. HCV antibody positive HWs were detected in 10 of 17 work places, and the prevalence rates in these departments or units varied between 1.2% and 6.5%. The prevalence increased gradually with increasing age, being 0% in these under 21 years of age and 9.5% in those above 50 years of age. Eleven (85%) of 13 HCV antibody positive HWs had HCV RNA in their sera, four of them intermittently during the follow-up period. HCV genotype 1 was present in two HWs, 1b in six HWs, 3a in one HW and 4 in two HWs. Chronic hepatitis C has developed in six (46%) HCV antibody positive HWs. 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| ispartof | The Journal of hospital infection, 2001-12, Vol.49 (4), p.239-244 |
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| subjects | Adult Age Distribution Aged Biological and medical sciences Female Genome, Human Health Status Hepatitis C Hepatitis C Antibodies - blood hepatitis C genotypes Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - genetics Human viral diseases Humans Hungary - epidemiology Immunoenzyme Techniques Infectious diseases Male Medical sciences Middle Aged Occupational Exposure occupational hazard Personnel, Hospital Prevalence Reverse Transcriptase Polymerase Chain Reaction Viral diseases Viral hepatitis |
| title | Prevalence, genotype distribution and outcome of hepatitis C infections among the employees of the Hungarian Central Hospital for Infectious Diseases |
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