Integration of Runx and Smad Regulatory Signals at Transcriptionally Active Subnuclear Sites

Runx factors control lineage commitment and are transcriptional effectors of Smad signaling. Genetic defects in these pathways interfere with normal development. The in situ localization of Runx and Smad proteins must impact the mechanisms by which these proteins function together in gene regulation...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-06, Vol.99 (12), p.8048-8053
Hauptverfasser:	Zaidi, Sayyed K., Sullivan, Andrew J., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Biological Sciences Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Bone Neoplasms Cell lines Cell nucleus Cell Nucleus - physiology Cells Cellular biology Cellular immunity Core Binding Factor alpha Subunits DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fluorescent antibody techniques Gene expression Genes HeLa Cells Humans Mammals Mutagenesis, Site-Directed Neoplasm Proteins Nuclear matrix Osteosarcoma Phosphoproteins - genetics Phosphoproteins - metabolism Proteins Rats Recombinant Proteins - metabolism Signal Transduction Smad5 Protein Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - drug effects Transfection Transforming Growth Factor beta - pharmacology Tumor Cells, Cultured
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