A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives

A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAdoR antagonists have been reported in literature, h...

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Veröffentlicht in:	European journal of medicinal chemistry 2017-02, Vol.127, p.986-996
Hauptverfasser:	Basu, Sujay, Barawkar, Dinesh A., Ramdas, Vidya, Waman, Yogesh, Patel, Meena, Panmand, Anil, Kumar, Santosh, Thorat, Sachin, Bonagiri, Rajesh, Jadhav, Dilip, Mukhopadhyay, Partha, Prasad, Vandna, Reddy, B. Srinivasa, Goswami, Arnab, Chaturvedi, Sandhya, Menon, Suraj, Quraishi, Azfar, Ghosh, Indraneel, Dusange, Sushant, Paliwal, Shalini, Kulkarni, Abhay, Karande, Vikas, Thakre, Rhishikesh, Bedse, Gaurav, Rouduri, Sreekanth, Gundu, Jayasagar, Palle, Venkata P., Chugh, Anita, Mookhtiar, Kasim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Oxopyrrolidine Adenosine receptors Mouse liver microsomes Pharmacokinetics Xanthine
Online-Zugang:	Volltext
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