Anti-inflammatory effect of novel analogs of natural enkephalinase inhibitors in a mouse model of experimental colitis

The pharmacotherapy of inflammatory bowel disease is difficult and currently available treatments bring mostly poor and unsatisfactory results. The purpose of this work was the synthesis of opiorphin, sialorphin, spinorphin and a series of their analogs and the characterization of their effect on de...

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Veröffentlicht in:	Future medicinal chemistry 2016-12, Vol.8 (18), p.2231-2243
Hauptverfasser:	Kamysz, El bieta, Sa aga, Maciej, Soboci ska, Ma gorzata, Gie do, Artur, Fichna, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	aminopeptidase N Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology colitis Colitis - drug therapy Colitis - metabolism Disease Models, Animal Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Mice molecular modeling Neprilysin - antagonists & inhibitors Neprilysin - metabolism neutral endopeptidase opiorphin peptide synthesis sialorphin spinorphin
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