Effects of the isoflavone 4′,5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage

Long-term psoralen plus ultraviolet A radiation (PUVA) therapy is associated with an increased risk of squamous cell carcinoma and malignant melanoma. Genistein (4′,5,7-trihydroxyisoflavone), a major isoflavone in soybeans and a specific inhibitor of protein tyrosine kinase, has been shown to inhibi...

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Veröffentlicht in:	Carcinogenesis (New York) 2002-02, Vol.23 (2), p.317-321
Hauptverfasser:	Shyong, Eileen Q., Lu, Yuhun, Lazinsky, Alison, Saladi, Rao N., Phelps, Robert G., Austin, Lisa M., Lebwohl, Mark, Wei, Huachen
Format:	Artikel
Sprache:	eng
Schlagworte:	7-trihydroxyisoflavone 8-methoxy-psoralen 8-MOP Acetone - chemistry Animals Anticarcinogenic Agents - pharmacology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Caspase 3 Caspases - biosynthesis Chemical agents dimethyl sulfoxide Dimethyl Sulfoxide - pharmacology DMSO DNA - radiation effects DNA Damage - drug effects DNA Damage - radiation effects Epidermis - metabolism Female Ficusin - pharmacology genistein Genistein - pharmacology Immunohistochemistry Medical sciences Mice Models, Biological Neoplasms, Radiation-Induced - prevention & control PARP PBS PCNA phosphate-buffered saline poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - biosynthesis psoralen plus ultraviolet A radiation PUVA Skin - drug effects Time Factors Tumors ultraviolet A radiation Ultraviolet Rays UVA
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