LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mice, tumors with reduced lactic acid production (Ld...

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Veröffentlicht in:	Cell metabolism 2016-11, Vol.24 (5), p.657-671
Hauptverfasser:	Brand, Almut, Singer, Katrin, Koehl, Gudrun E., Kolitzus, Marlene, Schoenhammer, Gabriele, Thiel, Annette, Matos, Carina, Bruss, Christina, Klobuch, Sebastian, Peter, Katrin, Kastenberger, Michael, Bogdan, Christian, Schleicher, Ulrike, Mackensen, Andreas, Ullrich, Evelyn, Fichtner-Feigl, Stefan, Kesselring, Rebecca, Mack, Matthias, Ritter, Uwe, Schmid, Maximilian, Blank, Christian, Dettmer, Katja, Oefner, Peter J., Hoffmann, Petra, Walenta, Stefan, Geissler, Edward K., Pouyssegur, Jacques, Villunger, Andreas, Steven, André, Seliger, Barbara, Schreml, Stephan, Haferkamp, Sebastian, Kohl, Elisabeth, Karrer, Sigrid, Berneburg, Mark, Herr, Wolfgang, Mueller-Klieser, Wolfgang, Renner, Kathrin, Kreutz, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects CD8-Positive T-Lymphocytes - immunology Cell Count Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - immunology Cytokines - biosynthesis Glycolysis - drug effects Humans Immunologic Surveillance - drug effects Interferon-gamma - pharmacology Isoenzymes - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - immunology L-Lactate Dehydrogenase - metabolism Lactic Acid - biosynthesis Lactic Acid - pharmacology Male Melanoma - immunology Melanoma - pathology Mice, Inbred C57BL NFATC Transcription Factors - metabolism Phenotype Sodium Lactate - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology Up-Regulation - drug effects
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