Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice

BACKGROUND AND PURPOSE—Growing evidence supports that the immunomodulatory drug fingolimod is protective in stroke. Fingolimod binds to 4 of 5 sphingosine-1-phosphate (S1P) receptors and, among other actions, it induces lymphopenia. In this study, we investigated whether a selective S1P1 agonist is...

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Veröffentlicht in:	Stroke (1970) 2016-12, Vol.47 (12), p.3053-3056
Hauptverfasser:	Brait, Vanessa H, Tarrasón, Gema, Gavaldà, Amadeu, Godessart, Núria, Planas, Anna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Infarction - drug therapy Fingolimod Hydrochloride - pharmacology Immunosuppressive Agents - pharmacology Lymphopenia - chemically induced Lysophospholipids - agonists Male Mice Mice, Inbred C57BL Neuroprotective Agents - pharmacology Receptors, Lysosphingolipid - agonists Reperfusion Injury - drug therapy Sphingosine - agonists Sphingosine - analogs & derivatives
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