Structure-activity relationship-based screening of antibiotics against Gram-negative Acinetobacter baumannii

[Display omitted] To discover potent antibiotics against the Gram-negative bacteria, we performed a structure-activity relationship (SAR) study of YKsa-6, which was the most potent inhibitor of Staphylococcus aureus β-ketoacyl acyl carrier protein III in our previous study. We identified and selecte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-01, Vol.25 (1), p.372-380
Hauptverfasser:	Lee, Jee-Young, Jeong, Min-Cheol, Jeon, Dasom, Lee, Yeongjun, Lee, Woo Cheol, Kim, Yangmee
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - antagonists & inhibitors Acinetobacter baumannii - drug effects Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibiotics Cell Line, Tumor Drug Evaluation, Preclinical Fatty acid synthesis Gram-negative bacteria Hydrazones - chemistry Hydrazones - pharmacology Hydrogen Bonding Hydrophobic and Hydrophilic Interactions In silico screening KAS Mice Molecular Docking Simulation Nitrites - metabolism Phenols - chemistry Phenols - pharmacology Resorcinols - chemistry Resorcinols - pharmacology RNA, Messenger - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!