The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling

Cardiac myofibroblasts play an important role in myocardial remodeling. Although α-smooth muscle actin (α-SMA) expression is the hallmark of mature myofibroblasts, its role in regulating fibroblast function remains poorly understood. We explore the effects of the matrix environment in modulating car...

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Veröffentlicht in:	Biochimica et biophysica acta 2017-01, Vol.1863 (1), p.298-309
Hauptverfasser:	Shinde, Arti V., Humeres, Claudio, Frangogiannis, Nikolaos G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cells, Cultured Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Male Mice, Inbred C57BL Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology Myofibroblast Myofibroblasts - metabolism Myofibroblasts - pathology Transforming Growth Factor beta1 - metabolism Transforming growth factor-β α-Smooth muscle actin
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