Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy
Purpose Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG). Methods This was a retrospective analysis of the prospectively c...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2017-07, Vol.47 (7), p.844-850 |
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| container_title | Surgery today (Tokyo, Japan) |
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| creator | Abdallah, Emad Emile, Sameh Hany Elfeki, Hossam Fikry, Mohamed Abdelshafy, Mahmoud Elshobaky, Ayman Elgendy, Hesham Thabet, Waleed Youssef, Mohamed Elghadban, Hosam Lotfy, Ahmed |
| description | Purpose
Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG).
Methods
This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients’ characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected.
Results
A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m
2
. Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (
P
= 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively.
Conclusion
The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL. |
| doi_str_mv | 10.1007/s00595-016-1446-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1839123944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1839123944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-369f514cc7bcfe48368f526565ff0491b6065d7aedcabf62ae1f1975f22d29ff3</originalsourceid><addsrcrecordid>eNp9kE1P7CAUhonR6PjxA9yYLt1UORRoWRrjVRMTE6NrwtCDVmmp0N7M_PvLOF6XrkgOz_vmnIeQU6AXQGl9mSgVSpQUZAmcy3K1QxbAK1myBqpdsqCKQwlMwQE5TOmdUsYbSvfJAaubqma1WJCPp-CxCK6YYwothtXavgXf2cLYri26oZjesBgj_sVh6sKwIV-N92kKAxYuxN58jY2bMBbejCaGZMOYC5LHnMp0miLaKfTrY7LnjE948v0ekZc_N8_Xd-XD4-399dVDaSvZTGUllRPAra2X1iFv8tAJJoUUzlGuYCmpFG1tsLVm6SQzCA5ULRxjLVPOVUfkfNs7xvA5Y5p03yWL3psBw5w0NJUCVinOMwpb1Oa9U0Snx9j1Jq41UL1xrLeOdXasN471KmfOvuvnZY_tT-K_1AywLZDy1_CKUb-HOQ755F9a_wFrfopl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1839123944</pqid></control><display><type>article</type><title>Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Abdallah, Emad ; Emile, Sameh Hany ; Elfeki, Hossam ; Fikry, Mohamed ; Abdelshafy, Mahmoud ; Elshobaky, Ayman ; Elgendy, Hesham ; Thabet, Waleed ; Youssef, Mohamed ; Elghadban, Hosam ; Lotfy, Ahmed</creator><creatorcontrib>Abdallah, Emad ; Emile, Sameh Hany ; Elfeki, Hossam ; Fikry, Mohamed ; Abdelshafy, Mahmoud ; Elshobaky, Ayman ; Elgendy, Hesham ; Thabet, Waleed ; Youssef, Mohamed ; Elghadban, Hosam ; Lotfy, Ahmed</creatorcontrib><description>Purpose
Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG).
Methods
This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients’ characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected.
Results
A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m
2
. Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (
P
= 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively.
Conclusion
The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-016-1446-x</identifier><identifier>PMID: 27837275</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Bariatric Surgery - methods ; Cholelithiasis - prevention & control ; Female ; Gastrectomy - methods ; Humans ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Obesity, Morbid - surgery ; Original Article ; Postoperative Complications - prevention & control ; Retrospective Studies ; Risk Factors ; Surgery ; Surgical Oncology ; Ursodeoxycholic Acid - administration & dosage ; Young Adult</subject><ispartof>Surgery today (Tokyo, Japan), 2017-07, Vol.47 (7), p.844-850</ispartof><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-369f514cc7bcfe48368f526565ff0491b6065d7aedcabf62ae1f1975f22d29ff3</citedby><cites>FETCH-LOGICAL-c368t-369f514cc7bcfe48368f526565ff0491b6065d7aedcabf62ae1f1975f22d29ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-016-1446-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-016-1446-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27837275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdallah, Emad</creatorcontrib><creatorcontrib>Emile, Sameh Hany</creatorcontrib><creatorcontrib>Elfeki, Hossam</creatorcontrib><creatorcontrib>Fikry, Mohamed</creatorcontrib><creatorcontrib>Abdelshafy, Mahmoud</creatorcontrib><creatorcontrib>Elshobaky, Ayman</creatorcontrib><creatorcontrib>Elgendy, Hesham</creatorcontrib><creatorcontrib>Thabet, Waleed</creatorcontrib><creatorcontrib>Youssef, Mohamed</creatorcontrib><creatorcontrib>Elghadban, Hosam</creatorcontrib><creatorcontrib>Lotfy, Ahmed</creatorcontrib><title>Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG).
Methods
This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients’ characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected.
Results
A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m
2
. Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (
P
= 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively.
Conclusion
The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL.</description><subject>Adult</subject><subject>Bariatric Surgery - methods</subject><subject>Cholelithiasis - prevention & control</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Article</subject><subject>Postoperative Complications - prevention & control</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Ursodeoxycholic Acid - administration & dosage</subject><subject>Young Adult</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P7CAUhonR6PjxA9yYLt1UORRoWRrjVRMTE6NrwtCDVmmp0N7M_PvLOF6XrkgOz_vmnIeQU6AXQGl9mSgVSpQUZAmcy3K1QxbAK1myBqpdsqCKQwlMwQE5TOmdUsYbSvfJAaubqma1WJCPp-CxCK6YYwothtXavgXf2cLYri26oZjesBgj_sVh6sKwIV-N92kKAxYuxN58jY2bMBbejCaGZMOYC5LHnMp0miLaKfTrY7LnjE948v0ekZc_N8_Xd-XD4-399dVDaSvZTGUllRPAra2X1iFv8tAJJoUUzlGuYCmpFG1tsLVm6SQzCA5ULRxjLVPOVUfkfNs7xvA5Y5p03yWL3psBw5w0NJUCVinOMwpb1Oa9U0Snx9j1Jq41UL1xrLeOdXasN471KmfOvuvnZY_tT-K_1AywLZDy1_CKUb-HOQ755F9a_wFrfopl</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Abdallah, Emad</creator><creator>Emile, Sameh Hany</creator><creator>Elfeki, Hossam</creator><creator>Fikry, Mohamed</creator><creator>Abdelshafy, Mahmoud</creator><creator>Elshobaky, Ayman</creator><creator>Elgendy, Hesham</creator><creator>Thabet, Waleed</creator><creator>Youssef, Mohamed</creator><creator>Elghadban, Hosam</creator><creator>Lotfy, Ahmed</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy</title><author>Abdallah, Emad ; Emile, Sameh Hany ; Elfeki, Hossam ; Fikry, Mohamed ; Abdelshafy, Mahmoud ; Elshobaky, Ayman ; Elgendy, Hesham ; Thabet, Waleed ; Youssef, Mohamed ; Elghadban, Hosam ; Lotfy, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-369f514cc7bcfe48368f526565ff0491b6065d7aedcabf62ae1f1975f22d29ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Bariatric Surgery - methods</topic><topic>Cholelithiasis - prevention & control</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Article</topic><topic>Postoperative Complications - prevention & control</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Ursodeoxycholic Acid - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdallah, Emad</creatorcontrib><creatorcontrib>Emile, Sameh Hany</creatorcontrib><creatorcontrib>Elfeki, Hossam</creatorcontrib><creatorcontrib>Fikry, Mohamed</creatorcontrib><creatorcontrib>Abdelshafy, Mahmoud</creatorcontrib><creatorcontrib>Elshobaky, Ayman</creatorcontrib><creatorcontrib>Elgendy, Hesham</creatorcontrib><creatorcontrib>Thabet, Waleed</creatorcontrib><creatorcontrib>Youssef, Mohamed</creatorcontrib><creatorcontrib>Elghadban, Hosam</creatorcontrib><creatorcontrib>Lotfy, Ahmed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdallah, Emad</au><au>Emile, Sameh Hany</au><au>Elfeki, Hossam</au><au>Fikry, Mohamed</au><au>Abdelshafy, Mahmoud</au><au>Elshobaky, Ayman</au><au>Elgendy, Hesham</au><au>Thabet, Waleed</au><au>Youssef, Mohamed</au><au>Elghadban, Hosam</au><au>Lotfy, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>47</volume><issue>7</issue><spage>844</spage><epage>850</epage><pages>844-850</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG).
Methods
This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients’ characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected.
Results
A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m
2
. Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (
P
= 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively.
Conclusion
The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27837275</pmid><doi>10.1007/s00595-016-1446-x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2017-07, Vol.47 (7), p.844-850 |
| issn | 0941-1291 1436-2813 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Bariatric Surgery - methods Cholelithiasis - prevention & control Female Gastrectomy - methods Humans Laparoscopy - methods Male Medicine Medicine & Public Health Obesity, Morbid - surgery Original Article Postoperative Complications - prevention & control Retrospective Studies Risk Factors Surgery Surgical Oncology Ursodeoxycholic Acid - administration & dosage Young Adult |
| title | Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy |
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