Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma
Background Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in pat...
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| Veröffentlicht in: | Annals of surgical oncology 2017-04, Vol.24 (4), p.1037-1045 |
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| creator | Okumura, Shinya Kaido, Toshimi Hamaguchi, Yuhei Kobayashi, Atsushi Shirai, Hisaya Fujimoto, Yasuhiro Iida, Taku Yagi, Shintaro Taura, Kojiro Hatano, Etsuro Okajima, Hideaki Uemoto, Shinji |
| description | Background
Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC).
Methods
A retrospective analysis was performed of 109 patients undergoing resections of ICC between January 2004 and April 2015. Skeletal muscle mass [skeletal muscle index (SMI)], skeletal muscle quality [muscle attenuation (MA)], and visceral adiposity [visceral to subcutaneous adipose tissue area ratio (VSR)] were measured on preoperative computed tomography images. The impacts of these parameters on outcomes after ICC resections were analyzed.
Results
The overall survival rates were significantly lower in patients with low SMI (
P
= 0.002), low MA (
P
= 0.032), and high VSR (
P
= 0.026) compared with patients with high SMI, high MA, and low VSR, respectively. With multivariate analyses, in patients with stage I–III, low SMI (hazard ratio (HR) 3.29,
P
= 0.003) and low MA (HR 2.86,
P
= 0.010) were revealed as independent significant risk factors for mortality. In patients with stage IV, none of these parameters was identified as risk factors, with only the absence of adjuvant chemotherapy identified as an independent risk factor for mortality (HR 5.92,
P
= 0.001).
Conclusions
Although stage was the most important factor, low skeletal muscle mass and quality were closely related to mortality after resection of ICC in patients with stage I–III. |
| doi_str_mv | 10.1245/s10434-016-5668-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1839121441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1839121441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-f628102280c361b711355c95aa083ed40e5a5ecb00260bc244a30a3406320fb73</originalsourceid><addsrcrecordid>eNp1kc1O3DAUhS1UBJTyAGyQpW66IHD9m8wSjUo7EghBW7aW43EGUycOtqOKR-hb19FAVVViZfvc7557rYPQMYEzQrk4TwQ44xUQWQkpm4rtoAMiisJlQ96VOxRxQaXYR-9TegQgNQOxh_Zp3bCaLuoD9HvVj9pkHDr87af1NmuPr6dkvMXXOqXT18ftpL3Lz6dYD2t875KxsZAXazeGVHQcBnwzZRN6m_Bl8D78csMG39lkTXalWPxXQ476wY46O4OXD8HrYeOC0dG4IfT6A9rttE_26OU8RD8uP39ffq2ubr6slhdXleGsyVUnaUOA0gYMk6StCWFCmIXQGhpm1xys0MKaFoBKaA3lXDPQjINkFLq2Zofo09Z3jOFpsimrfv6OL-vYMCVFGrYglHBOCvrxP_QxTHEo2xWq5vMmjBWKbCkTQ0rRdmqMrtfxWRFQc05qm5MqOak5JzX3nLw4T21v1387XoMpAN0CqZSGjY3_jH7T9Q_I3J19</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874628133</pqid></control><display><type>article</type><title>Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Okumura, Shinya ; Kaido, Toshimi ; Hamaguchi, Yuhei ; Kobayashi, Atsushi ; Shirai, Hisaya ; Fujimoto, Yasuhiro ; Iida, Taku ; Yagi, Shintaro ; Taura, Kojiro ; Hatano, Etsuro ; Okajima, Hideaki ; Uemoto, Shinji</creator><creatorcontrib>Okumura, Shinya ; Kaido, Toshimi ; Hamaguchi, Yuhei ; Kobayashi, Atsushi ; Shirai, Hisaya ; Fujimoto, Yasuhiro ; Iida, Taku ; Yagi, Shintaro ; Taura, Kojiro ; Hatano, Etsuro ; Okajima, Hideaki ; Uemoto, Shinji</creatorcontrib><description>Background
Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC).
Methods
A retrospective analysis was performed of 109 patients undergoing resections of ICC between January 2004 and April 2015. Skeletal muscle mass [skeletal muscle index (SMI)], skeletal muscle quality [muscle attenuation (MA)], and visceral adiposity [visceral to subcutaneous adipose tissue area ratio (VSR)] were measured on preoperative computed tomography images. The impacts of these parameters on outcomes after ICC resections were analyzed.
Results
The overall survival rates were significantly lower in patients with low SMI (
P
= 0.002), low MA (
P
= 0.032), and high VSR (
P
= 0.026) compared with patients with high SMI, high MA, and low VSR, respectively. With multivariate analyses, in patients with stage I–III, low SMI (hazard ratio (HR) 3.29,
P
= 0.003) and low MA (HR 2.86,
P
= 0.010) were revealed as independent significant risk factors for mortality. In patients with stage IV, none of these parameters was identified as risk factors, with only the absence of adjuvant chemotherapy identified as an independent risk factor for mortality (HR 5.92,
P
= 0.001).
Conclusions
Although stage was the most important factor, low skeletal muscle mass and quality were closely related to mortality after resection of ICC in patients with stage I–III.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-016-5668-3</identifier><identifier>PMID: 27837297</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Area Under Curve ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Disease-Free Survival ; Female ; Hepatobiliary Tumors ; Humans ; Intra-Abdominal Fat - diagnostic imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multidetector Computed Tomography ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - physiopathology ; Neoplasm Staging ; Oncology ; Preoperative Period ; Retrospective Studies ; Risk Factors ; ROC Curve ; Surgery ; Surgical Oncology ; Survival Rate ; Treatment Outcome</subject><ispartof>Annals of surgical oncology, 2017-04, Vol.24 (4), p.1037-1045</ispartof><rights>Society of Surgical Oncology 2016</rights><rights>Annals of Surgical Oncology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f628102280c361b711355c95aa083ed40e5a5ecb00260bc244a30a3406320fb73</citedby><cites>FETCH-LOGICAL-c438t-f628102280c361b711355c95aa083ed40e5a5ecb00260bc244a30a3406320fb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-016-5668-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-016-5668-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27837297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okumura, Shinya</creatorcontrib><creatorcontrib>Kaido, Toshimi</creatorcontrib><creatorcontrib>Hamaguchi, Yuhei</creatorcontrib><creatorcontrib>Kobayashi, Atsushi</creatorcontrib><creatorcontrib>Shirai, Hisaya</creatorcontrib><creatorcontrib>Fujimoto, Yasuhiro</creatorcontrib><creatorcontrib>Iida, Taku</creatorcontrib><creatorcontrib>Yagi, Shintaro</creatorcontrib><creatorcontrib>Taura, Kojiro</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><creatorcontrib>Okajima, Hideaki</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><title>Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC).
Methods
A retrospective analysis was performed of 109 patients undergoing resections of ICC between January 2004 and April 2015. Skeletal muscle mass [skeletal muscle index (SMI)], skeletal muscle quality [muscle attenuation (MA)], and visceral adiposity [visceral to subcutaneous adipose tissue area ratio (VSR)] were measured on preoperative computed tomography images. The impacts of these parameters on outcomes after ICC resections were analyzed.
Results
The overall survival rates were significantly lower in patients with low SMI (
P
= 0.002), low MA (
P
= 0.032), and high VSR (
P
= 0.026) compared with patients with high SMI, high MA, and low VSR, respectively. With multivariate analyses, in patients with stage I–III, low SMI (hazard ratio (HR) 3.29,
P
= 0.003) and low MA (HR 2.86,
P
= 0.010) were revealed as independent significant risk factors for mortality. In patients with stage IV, none of these parameters was identified as risk factors, with only the absence of adjuvant chemotherapy identified as an independent risk factor for mortality (HR 5.92,
P
= 0.001).
Conclusions
Although stage was the most important factor, low skeletal muscle mass and quality were closely related to mortality after resection of ICC in patients with stage I–III.</description><subject>Aged</subject><subject>Area Under Curve</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Bile Ducts, Intrahepatic</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hepatobiliary Tumors</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Preoperative Period</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1O3DAUhS1UBJTyAGyQpW66IHD9m8wSjUo7EghBW7aW43EGUycOtqOKR-hb19FAVVViZfvc7557rYPQMYEzQrk4TwQ44xUQWQkpm4rtoAMiisJlQ96VOxRxQaXYR-9TegQgNQOxh_Zp3bCaLuoD9HvVj9pkHDr87af1NmuPr6dkvMXXOqXT18ftpL3Lz6dYD2t875KxsZAXazeGVHQcBnwzZRN6m_Bl8D78csMG39lkTXalWPxXQ476wY46O4OXD8HrYeOC0dG4IfT6A9rttE_26OU8RD8uP39ffq2ubr6slhdXleGsyVUnaUOA0gYMk6StCWFCmIXQGhpm1xys0MKaFoBKaA3lXDPQjINkFLq2Zofo09Z3jOFpsimrfv6OL-vYMCVFGrYglHBOCvrxP_QxTHEo2xWq5vMmjBWKbCkTQ0rRdmqMrtfxWRFQc05qm5MqOak5JzX3nLw4T21v1387XoMpAN0CqZSGjY3_jH7T9Q_I3J19</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Okumura, Shinya</creator><creator>Kaido, Toshimi</creator><creator>Hamaguchi, Yuhei</creator><creator>Kobayashi, Atsushi</creator><creator>Shirai, Hisaya</creator><creator>Fujimoto, Yasuhiro</creator><creator>Iida, Taku</creator><creator>Yagi, Shintaro</creator><creator>Taura, Kojiro</creator><creator>Hatano, Etsuro</creator><creator>Okajima, Hideaki</creator><creator>Uemoto, Shinji</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma</title><author>Okumura, Shinya ; Kaido, Toshimi ; Hamaguchi, Yuhei ; Kobayashi, Atsushi ; Shirai, Hisaya ; Fujimoto, Yasuhiro ; Iida, Taku ; Yagi, Shintaro ; Taura, Kojiro ; Hatano, Etsuro ; Okajima, Hideaki ; Uemoto, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f628102280c361b711355c95aa083ed40e5a5ecb00260bc244a30a3406320fb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Area Under Curve</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Bile Ducts, Intrahepatic</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hepatobiliary Tumors</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Preoperative Period</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okumura, Shinya</creatorcontrib><creatorcontrib>Kaido, Toshimi</creatorcontrib><creatorcontrib>Hamaguchi, Yuhei</creatorcontrib><creatorcontrib>Kobayashi, Atsushi</creatorcontrib><creatorcontrib>Shirai, Hisaya</creatorcontrib><creatorcontrib>Fujimoto, Yasuhiro</creatorcontrib><creatorcontrib>Iida, Taku</creatorcontrib><creatorcontrib>Yagi, Shintaro</creatorcontrib><creatorcontrib>Taura, Kojiro</creatorcontrib><creatorcontrib>Hatano, Etsuro</creatorcontrib><creatorcontrib>Okajima, Hideaki</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okumura, Shinya</au><au>Kaido, Toshimi</au><au>Hamaguchi, Yuhei</au><au>Kobayashi, Atsushi</au><au>Shirai, Hisaya</au><au>Fujimoto, Yasuhiro</au><au>Iida, Taku</au><au>Yagi, Shintaro</au><au>Taura, Kojiro</au><au>Hatano, Etsuro</au><au>Okajima, Hideaki</au><au>Uemoto, Shinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>24</volume><issue>4</issue><spage>1037</spage><epage>1045</epage><pages>1037-1045</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC).
Methods
A retrospective analysis was performed of 109 patients undergoing resections of ICC between January 2004 and April 2015. Skeletal muscle mass [skeletal muscle index (SMI)], skeletal muscle quality [muscle attenuation (MA)], and visceral adiposity [visceral to subcutaneous adipose tissue area ratio (VSR)] were measured on preoperative computed tomography images. The impacts of these parameters on outcomes after ICC resections were analyzed.
Results
The overall survival rates were significantly lower in patients with low SMI (
P
= 0.002), low MA (
P
= 0.032), and high VSR (
P
= 0.026) compared with patients with high SMI, high MA, and low VSR, respectively. With multivariate analyses, in patients with stage I–III, low SMI (hazard ratio (HR) 3.29,
P
= 0.003) and low MA (HR 2.86,
P
= 0.010) were revealed as independent significant risk factors for mortality. In patients with stage IV, none of these parameters was identified as risk factors, with only the absence of adjuvant chemotherapy identified as an independent risk factor for mortality (HR 5.92,
P
= 0.001).
Conclusions
Although stage was the most important factor, low skeletal muscle mass and quality were closely related to mortality after resection of ICC in patients with stage I–III.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27837297</pmid><doi>10.1245/s10434-016-5668-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2017-04, Vol.24 (4), p.1037-1045 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Area Under Curve Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Disease-Free Survival Female Hepatobiliary Tumors Humans Intra-Abdominal Fat - diagnostic imaging Male Medicine Medicine & Public Health Middle Aged Multidetector Computed Tomography Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - physiopathology Neoplasm Staging Oncology Preoperative Period Retrospective Studies Risk Factors ROC Curve Surgery Surgical Oncology Survival Rate Treatment Outcome |
| title | Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma |
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