Cortisol reactivity and suicidal behavior: investigating the role of hypothalamic-pituitary-adrenal axis responses to stress in suicide attempters and ideators

Highlights • Participants who had made a previous suicide attempt exhibited significantly lower cortisol response to acute stress. • Participants who made an attempt within the past year exhibited a blunted cortisol response compared to participants with a more distant history of attempt. • Particip...

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Veröffentlicht in:Psychoneuroendocrinology 2017-01, Vol.75, p.183-191
Hauptverfasser: O’Connor, Daryl B., PhD, Green, Jessica A., MSc, Ferguson, Eamonn, PhD, O’Carroll, Ronan E., PhD, O’Connor, Rory C., PhD
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container_end_page 191
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container_start_page 183
container_title Psychoneuroendocrinology
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creator O’Connor, Daryl B., PhD
Green, Jessica A., MSc
Ferguson, Eamonn, PhD
O’Carroll, Ronan E., PhD
O’Connor, Rory C., PhD
description Highlights • Participants who had made a previous suicide attempt exhibited significantly lower cortisol response to acute stress. • Participants who made an attempt within the past year exhibited a blunted cortisol response compared to participants with a more distant history of attempt. • Participants who had made a suicide attempt and had a family history of suicide also exhibited a blunted cortisol response to stress. • Lower levels of cortisol in response to acute stress were associated with higher levels of suicidal ideation at 1-month follow-up in the suicide attempters group
doi_str_mv 10.1016/j.psyneuen.2016.10.019
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subjects Adolescent
Adult
Allostatic load
Chronic stress
Cortisol reactivity
Endocrinology & Metabolism
Female
HPA axis
Humans
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - metabolism
Male
Middle Aged
Pituitary-Adrenal System - metabolism
Psychiatry
Self-harm
Stress, Psychological - metabolism
Suicidal Ideation
Suicide, Attempted
Young Adult
title Cortisol reactivity and suicidal behavior: investigating the role of hypothalamic-pituitary-adrenal axis responses to stress in suicide attempters and ideators
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