One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa
To determine the feasibility of a 49-channel suprachoroidal-transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year. Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implant...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2016-11, Vol.57 (14), p.6147-6157 |
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| creator | Fujikado, Takashi Kamei, Motohiro Sakaguchi, Hirokazu Kanda, Hiroyuki Endo, Takao Hirota, Masakazu Morimoto, Takeshi Nishida, Kentaro Kishima, Haruhiko Terasawa, Yasuo Oosawa, Koji Ozawa, Motoki Nishida, Kohji |
| description | To determine the feasibility of a 49-channel suprachoroidal-transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year.
Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implanted in a scleral pocket, and the stability of the prosthesis, adverse events, and its efficacy were investigated.
The electrode array was implanted in a scleral pocket located under the parafoveal area through a scleral incision at 14 mm in patient (Pt) 1, 16 mm in Pt 2, and 18 mm in Pt 3 from the sclerocorneal limbus. No complications occurred during surgery in all cases. During the follow-up period, iridocyclitis developed in Pt 2 and Pt 3, which was successfully treated with topical medications. The implanted devices continued functioning and elicited phosphenes in all cases. The results of localization tests (P < 0.05) and table tests (P < 0.05) were significantly better with the prosthesis turned on than turned off in Pt 3. The deviations of the walking tests were smaller with the prosthesis turned on than off in Pt 2 and Pt 3 at multiple times after the implantation.
The 49-channel STS retinal prosthesis was able to elicit phosphenes in all patients with advanced RP for the entire 1-year experimental period without major complications. Better results on visual tasks were found in the eyes in which the electrode array was implanted closer to the fovea centralis. |
| doi_str_mv | 10.1167/iovs.16-20367 |
| format | Article |
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Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implanted in a scleral pocket, and the stability of the prosthesis, adverse events, and its efficacy were investigated.
The electrode array was implanted in a scleral pocket located under the parafoveal area through a scleral incision at 14 mm in patient (Pt) 1, 16 mm in Pt 2, and 18 mm in Pt 3 from the sclerocorneal limbus. No complications occurred during surgery in all cases. During the follow-up period, iridocyclitis developed in Pt 2 and Pt 3, which was successfully treated with topical medications. The implanted devices continued functioning and elicited phosphenes in all cases. The results of localization tests (P < 0.05) and table tests (P < 0.05) were significantly better with the prosthesis turned on than turned off in Pt 3. The deviations of the walking tests were smaller with the prosthesis turned on than off in Pt 2 and Pt 3 at multiple times after the implantation.
The 49-channel STS retinal prosthesis was able to elicit phosphenes in all patients with advanced RP for the entire 1-year experimental period without major complications. Better results on visual tasks were found in the eyes in which the electrode array was implanted closer to the fovea centralis.</description><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.16-20367</identifier><identifier>PMID: 27835711</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Choroid - physiopathology ; Electric Stimulation - methods ; Evoked Potentials, Visual ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Retina - physiopathology ; Retinitis Pigmentosa - physiopathology ; Retinitis Pigmentosa - therapy ; Time Factors ; Treatment Outcome ; Visual Acuity ; Visual Prosthesis</subject><ispartof>Investigative ophthalmology & visual science, 2016-11, Vol.57 (14), p.6147-6157</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-74e12ac71a3e42dadc095cd70102a73d42bf067cb2587e8afb246551402539fe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27835711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujikado, Takashi</creatorcontrib><creatorcontrib>Kamei, Motohiro</creatorcontrib><creatorcontrib>Sakaguchi, Hirokazu</creatorcontrib><creatorcontrib>Kanda, Hiroyuki</creatorcontrib><creatorcontrib>Endo, Takao</creatorcontrib><creatorcontrib>Hirota, Masakazu</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Nishida, Kentaro</creatorcontrib><creatorcontrib>Kishima, Haruhiko</creatorcontrib><creatorcontrib>Terasawa, Yasuo</creatorcontrib><creatorcontrib>Oosawa, Koji</creatorcontrib><creatorcontrib>Ozawa, Motoki</creatorcontrib><creatorcontrib>Nishida, Kohji</creatorcontrib><title>One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To determine the feasibility of a 49-channel suprachoroidal-transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year.
Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implanted in a scleral pocket, and the stability of the prosthesis, adverse events, and its efficacy were investigated.
The electrode array was implanted in a scleral pocket located under the parafoveal area through a scleral incision at 14 mm in patient (Pt) 1, 16 mm in Pt 2, and 18 mm in Pt 3 from the sclerocorneal limbus. No complications occurred during surgery in all cases. During the follow-up period, iridocyclitis developed in Pt 2 and Pt 3, which was successfully treated with topical medications. The implanted devices continued functioning and elicited phosphenes in all cases. The results of localization tests (P < 0.05) and table tests (P < 0.05) were significantly better with the prosthesis turned on than turned off in Pt 3. The deviations of the walking tests were smaller with the prosthesis turned on than off in Pt 2 and Pt 3 at multiple times after the implantation.
The 49-channel STS retinal prosthesis was able to elicit phosphenes in all patients with advanced RP for the entire 1-year experimental period without major complications. Better results on visual tasks were found in the eyes in which the electrode array was implanted closer to the fovea centralis.</description><subject>Adult</subject><subject>Aged</subject><subject>Choroid - physiopathology</subject><subject>Electric Stimulation - methods</subject><subject>Evoked Potentials, Visual</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Retina - physiopathology</subject><subject>Retinitis Pigmentosa - physiopathology</subject><subject>Retinitis Pigmentosa - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><subject>Visual Prosthesis</subject><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1vFDEMxSMEoh9w5Ipy5JISJ5PJzrFaUUCqtBVthTiNvBkPGzSTLEmmEjf-dLJtqXqy_fyzpfcYewfyDKC1H328y2fQCiV1a1-wYzBGCWNX-uWz_oid5PxLSgWg5Gt2pKpmLMAx-7sJJH4QJr5Ziosz8TjyphPrHYZAE79e9gndLqboB5zETcKQExUfsO6Kn5cJi4-BX6WYy46yz9zXqYoUSubffdnx8-EOg6OBfzsc-lKZK_9zrkDM-Ia9GnHK9PaxnrLbi0836y_icvP56_r8UjitVRG2IVDoLKCmRg04ONkZN1gJUqHVQ6O2o2yt2yqzsrTCcaua1hhopDK6G0mfsg8Pf_cp_l4ol3722dE0YaC45B5WugPoGmkqKh5QV01Vt2O_T37G9KcH2R9C7w-h99D296FX_v3j62U70_BE_09Z_wMNv3-A</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Fujikado, Takashi</creator><creator>Kamei, Motohiro</creator><creator>Sakaguchi, Hirokazu</creator><creator>Kanda, Hiroyuki</creator><creator>Endo, Takao</creator><creator>Hirota, Masakazu</creator><creator>Morimoto, Takeshi</creator><creator>Nishida, Kentaro</creator><creator>Kishima, Haruhiko</creator><creator>Terasawa, Yasuo</creator><creator>Oosawa, Koji</creator><creator>Ozawa, Motoki</creator><creator>Nishida, Kohji</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa</title><author>Fujikado, Takashi ; Kamei, Motohiro ; Sakaguchi, Hirokazu ; Kanda, Hiroyuki ; Endo, Takao ; Hirota, Masakazu ; Morimoto, Takeshi ; Nishida, Kentaro ; Kishima, Haruhiko ; Terasawa, Yasuo ; Oosawa, Koji ; Ozawa, Motoki ; Nishida, Kohji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-74e12ac71a3e42dadc095cd70102a73d42bf067cb2587e8afb246551402539fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Choroid - physiopathology</topic><topic>Electric Stimulation - methods</topic><topic>Evoked Potentials, Visual</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Retina - physiopathology</topic><topic>Retinitis Pigmentosa - physiopathology</topic><topic>Retinitis Pigmentosa - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><topic>Visual Prosthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujikado, Takashi</creatorcontrib><creatorcontrib>Kamei, Motohiro</creatorcontrib><creatorcontrib>Sakaguchi, Hirokazu</creatorcontrib><creatorcontrib>Kanda, Hiroyuki</creatorcontrib><creatorcontrib>Endo, Takao</creatorcontrib><creatorcontrib>Hirota, Masakazu</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Nishida, Kentaro</creatorcontrib><creatorcontrib>Kishima, Haruhiko</creatorcontrib><creatorcontrib>Terasawa, Yasuo</creatorcontrib><creatorcontrib>Oosawa, Koji</creatorcontrib><creatorcontrib>Ozawa, Motoki</creatorcontrib><creatorcontrib>Nishida, Kohji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujikado, Takashi</au><au>Kamei, Motohiro</au><au>Sakaguchi, Hirokazu</au><au>Kanda, Hiroyuki</au><au>Endo, Takao</au><au>Hirota, Masakazu</au><au>Morimoto, Takeshi</au><au>Nishida, Kentaro</au><au>Kishima, Haruhiko</au><au>Terasawa, Yasuo</au><au>Oosawa, Koji</au><au>Ozawa, Motoki</au><au>Nishida, Kohji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>57</volume><issue>14</issue><spage>6147</spage><epage>6157</epage><pages>6147-6157</pages><issn>1552-5783</issn><eissn>1552-5783</eissn><abstract>To determine the feasibility of a 49-channel suprachoroidal-transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year.
Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implanted in a scleral pocket, and the stability of the prosthesis, adverse events, and its efficacy were investigated.
The electrode array was implanted in a scleral pocket located under the parafoveal area through a scleral incision at 14 mm in patient (Pt) 1, 16 mm in Pt 2, and 18 mm in Pt 3 from the sclerocorneal limbus. No complications occurred during surgery in all cases. During the follow-up period, iridocyclitis developed in Pt 2 and Pt 3, which was successfully treated with topical medications. The implanted devices continued functioning and elicited phosphenes in all cases. The results of localization tests (P < 0.05) and table tests (P < 0.05) were significantly better with the prosthesis turned on than turned off in Pt 3. The deviations of the walking tests were smaller with the prosthesis turned on than off in Pt 2 and Pt 3 at multiple times after the implantation.
The 49-channel STS retinal prosthesis was able to elicit phosphenes in all patients with advanced RP for the entire 1-year experimental period without major complications. Better results on visual tasks were found in the eyes in which the electrode array was implanted closer to the fovea centralis.</abstract><cop>United States</cop><pmid>27835711</pmid><doi>10.1167/iovs.16-20367</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Choroid - physiopathology Electric Stimulation - methods Evoked Potentials, Visual Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Pilot Projects Prospective Studies Retina - physiopathology Retinitis Pigmentosa - physiopathology Retinitis Pigmentosa - therapy Time Factors Treatment Outcome Visual Acuity Visual Prosthesis |
| title | One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa |
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