The road to restoring neural circuits for the treatment of Alzheimer's disease
Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These...
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| Veröffentlicht in: | Nature (London) 2016-11, Vol.539 (7628), p.187-196 |
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| creator | Canter, Rebecca G. Penney, Jay Tsai, Li-Huei |
| description | Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease. |
| doi_str_mv | 10.1038/nature20412 |
| format | Article |
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Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. 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| subjects | 631/378 692/699 Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - metabolism Animal cognition Animals Brain Care and treatment Clinical trials Cognition - drug effects Cognitive ability Disease Progression Genes Genetic engineering Health aspects Humanities and Social Sciences Humans Memory multidisciplinary Mutation Neural circuitry Neural Pathways - drug effects Neural Pathways - pathology Neurodegeneration Peptides Proteins review-article Science Synapses - metabolism |
| title | The road to restoring neural circuits for the treatment of Alzheimer's disease |
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