Pulmonary Arterial Hypertension and the Sex Hormone Paradox
Purpose of Review Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on he...
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| Veröffentlicht in: | Current hypertension reports 2016-11, Vol.18 (11), p.84-84, Article 84 |
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| creator | Foderaro, Andrew Ventetuolo, Corey E. |
| description | Purpose of Review
Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on heart-lung function in health and in disease.
Recent Findings
Female sex has been shown to be a risk factor for the development of PAH, but women have improved survival compared to men with PAH. These paradoxical observations are likely driven in part by complex sex hormone signaling and processing pathways and their interaction with the pulmonary vasculature and the right ventricle. These relationships may vary depending on an individual’s underlying sex, age, and/or genetic substrate.
Summary
The study of the connections between sex, sex hormones, the pulmonary circulation, and the right ventricle may improve our understanding of disease epidemiology and outcomes and lead to new treatment strategies for PAH. |
| doi_str_mv | 10.1007/s11906-016-0689-7 |
| format | Article |
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Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on heart-lung function in health and in disease.
Recent Findings
Female sex has been shown to be a risk factor for the development of PAH, but women have improved survival compared to men with PAH. These paradoxical observations are likely driven in part by complex sex hormone signaling and processing pathways and their interaction with the pulmonary vasculature and the right ventricle. These relationships may vary depending on an individual’s underlying sex, age, and/or genetic substrate.
Summary
The study of the connections between sex, sex hormones, the pulmonary circulation, and the right ventricle may improve our understanding of disease epidemiology and outcomes and lead to new treatment strategies for PAH.</description><identifier>ISSN: 1522-6417</identifier><identifier>EISSN: 1534-3111</identifier><identifier>DOI: 10.1007/s11906-016-0689-7</identifier><identifier>PMID: 27832457</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Cardiology ; Family Medicine ; General Practice ; Gonadal Steroid Hormones - metabolism ; Humans ; Hypertension ; Hypertension, Pulmonary - metabolism ; Hypertension, Pulmonary - physiopathology ; Internal Medicine ; Lung - blood supply ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nephrology ; Primary Care Medicine ; Pulmonary Hypertension (J Klinger ; Risk Factors ; Section Editor ; Sex Characteristics ; Topical Collection on Pulmonary Hypertension</subject><ispartof>Current hypertension reports, 2016-11, Vol.18 (11), p.84-84, Article 84</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Current Hypertension Reports is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ea9e7c2ab1fd91e3faf9b89cd4d4149771cae5522f98d8a0f097157a6831650b3</citedby><cites>FETCH-LOGICAL-c438t-ea9e7c2ab1fd91e3faf9b89cd4d4149771cae5522f98d8a0f097157a6831650b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11906-016-0689-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11906-016-0689-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,776,780,788,27901,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27832457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foderaro, Andrew</creatorcontrib><creatorcontrib>Ventetuolo, Corey E.</creatorcontrib><title>Pulmonary Arterial Hypertension and the Sex Hormone Paradox</title><title>Current hypertension reports</title><addtitle>Curr Hypertens Rep</addtitle><addtitle>Curr Hypertens Rep</addtitle><description>Purpose of Review
Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on heart-lung function in health and in disease.
Recent Findings
Female sex has been shown to be a risk factor for the development of PAH, but women have improved survival compared to men with PAH. These paradoxical observations are likely driven in part by complex sex hormone signaling and processing pathways and their interaction with the pulmonary vasculature and the right ventricle. These relationships may vary depending on an individual’s underlying sex, age, and/or genetic substrate.
Summary
The study of the connections between sex, sex hormones, the pulmonary circulation, and the right ventricle may improve our understanding of disease epidemiology and outcomes and lead to new treatment strategies for PAH.</description><subject>Animals</subject><subject>Cardiology</subject><subject>Family Medicine</subject><subject>General Practice</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - metabolism</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Internal Medicine</subject><subject>Lung - blood supply</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nephrology</subject><subject>Primary Care Medicine</subject><subject>Pulmonary Hypertension (J Klinger</subject><subject>Risk Factors</subject><subject>Section Editor</subject><subject>Sex Characteristics</subject><subject>Topical Collection on Pulmonary Hypertension</subject><issn>1522-6417</issn><issn>1534-3111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kFFLwzAQx4Mobk4_gC9S8MWXaq5pmwSfxlAnCA7U55C2V-1om5m0sH17UzpFBB9CDu73vzt-hJwDvQZK-Y0DkDQNKfiXChnyAzKFhMUhA4DDoY6iMI2BT8iJc2tKI5_ix2QSccGiOOFTcrvq68a02u6Cue3QVroOlrsN-rp1lWkD3RZB94HBC26DpbGexWClrS7M9pQclbp2eLb_Z-Tt_u51sQyfnh8eF_OnMI-Z6ELUEnke6QzKQgKyUpcyEzIv4iKGWHIOucbEn1pKUQhNSyo5JFyngkGa0IzNyNU4d2PNZ4-uU03lcqxr3aLpnQLBJIDfRT16-Qddm962_rqBEhEVLBkoGKncGucslmpjq8Y7UEDVYFaNZpU3qwazivvMxX5ynzVY_CS-VXogGgHnW-072l-r_536BcMpggI</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Foderaro, Andrew</creator><creator>Ventetuolo, Corey E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Pulmonary Arterial Hypertension and the Sex Hormone Paradox</title><author>Foderaro, Andrew ; Ventetuolo, Corey E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ea9e7c2ab1fd91e3faf9b89cd4d4149771cae5522f98d8a0f097157a6831650b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cardiology</topic><topic>Family Medicine</topic><topic>General Practice</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - metabolism</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Internal Medicine</topic><topic>Lung - blood supply</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Nephrology</topic><topic>Primary Care Medicine</topic><topic>Pulmonary Hypertension (J Klinger</topic><topic>Risk Factors</topic><topic>Section Editor</topic><topic>Sex Characteristics</topic><topic>Topical Collection on Pulmonary Hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foderaro, Andrew</creatorcontrib><creatorcontrib>Ventetuolo, Corey E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Current hypertension reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foderaro, Andrew</au><au>Ventetuolo, Corey E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Arterial Hypertension and the Sex Hormone Paradox</atitle><jtitle>Current hypertension reports</jtitle><stitle>Curr Hypertens Rep</stitle><addtitle>Curr Hypertens Rep</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>18</volume><issue>11</issue><spage>84</spage><epage>84</epage><pages>84-84</pages><artnum>84</artnum><issn>1522-6417</issn><eissn>1534-3111</eissn><abstract>Purpose of Review
Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on heart-lung function in health and in disease.
Recent Findings
Female sex has been shown to be a risk factor for the development of PAH, but women have improved survival compared to men with PAH. These paradoxical observations are likely driven in part by complex sex hormone signaling and processing pathways and their interaction with the pulmonary vasculature and the right ventricle. These relationships may vary depending on an individual’s underlying sex, age, and/or genetic substrate.
Summary
The study of the connections between sex, sex hormones, the pulmonary circulation, and the right ventricle may improve our understanding of disease epidemiology and outcomes and lead to new treatment strategies for PAH.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27832457</pmid><doi>10.1007/s11906-016-0689-7</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Cardiology Family Medicine General Practice Gonadal Steroid Hormones - metabolism Humans Hypertension Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Internal Medicine Lung - blood supply Medicine Medicine & Public Health Metabolic Diseases Nephrology Primary Care Medicine Pulmonary Hypertension (J Klinger Risk Factors Section Editor Sex Characteristics Topical Collection on Pulmonary Hypertension |
| title | Pulmonary Arterial Hypertension and the Sex Hormone Paradox |
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