Excess Pressure Integral Predicts Long-Term All-Cause Mortality in Stable Heart Failure Patients

Excess pressure integral (XSPI) derived from reservoir-excess pressure analysis is proposed as a novel indicator of cardiovascular dysfunction in hypertensives. Our study investigated the prognostic value of XSPI for stable heart failure (HF) patients. In total, 238 subjects (mean age 63 ± 18 years,...

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Veröffentlicht in:American journal of hypertension 2017-03, Vol.30 (3), p.271-278
Hauptverfasser: Wang, Wei-Ting, Sung, Shih-Hsien, Wang, Jiun-Jr, Wu, Cho-Kai, Lin, Lian-Yu, Lee, Jia-Chun, Cheng, Hao-Min, Chen, Chen-Huan
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container_end_page 278
container_issue 3
container_start_page 271
container_title American journal of hypertension
container_volume 30
creator Wang, Wei-Ting
Sung, Shih-Hsien
Wang, Jiun-Jr
Wu, Cho-Kai
Lin, Lian-Yu
Lee, Jia-Chun
Cheng, Hao-Min
Chen, Chen-Huan
description Excess pressure integral (XSPI) derived from reservoir-excess pressure analysis is proposed as a novel indicator of cardiovascular dysfunction in hypertensives. Our study investigated the prognostic value of XSPI for stable heart failure (HF) patients. In total, 238 subjects (mean age 63 ± 18 years, 111 male), comprising 168 stable HF patients with either reduced (SHF; n = 64) left ventricular (LV) ejection fraction (EF) or isolated diastolic dysfunction (DHF, n = 104), and 70 healthy controls, were enrolled. Tonometry-derived carotid pressure waveforms were analyzed with the reservoir pressure theory. XSPI was calculated by subtracting the reservoir pressure from carotid pressure waveform. XSPI in SHF and DHF (14.01 ± 5.16 and 13.90 ± 5.05 mm Hg•s) were significantly higher than that in controls (11.01 ± 3.67 mm Hg•s, both P < 0.001). During a median follow-up of 9.9 years, 56 deaths occurred. XSPI was a significant independent predictor of total mortality after adjusting for age, sex, left ventricular ejection fraction (LVEF), glomerular filtration rate (GFR), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (hazard ratio = 4.37 per 1 SD, 95% confidence interval, 1.31-14.58). In subgroup analysis by different baseline characteristics including age, gender, NT-proBNP, LVEF, and GFR, higher XSPI was consistently associated with greater risk of total mortality. In patients with stable HF, XSPI, a novel maker of cardiovascular dysfunction, was associated with long-term risk of total mortality.
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Our study investigated the prognostic value of XSPI for stable heart failure (HF) patients. In total, 238 subjects (mean age 63 ± 18 years, 111 male), comprising 168 stable HF patients with either reduced (SHF; n = 64) left ventricular (LV) ejection fraction (EF) or isolated diastolic dysfunction (DHF, n = 104), and 70 healthy controls, were enrolled. Tonometry-derived carotid pressure waveforms were analyzed with the reservoir pressure theory. XSPI was calculated by subtracting the reservoir pressure from carotid pressure waveform. XSPI in SHF and DHF (14.01 ± 5.16 and 13.90 ± 5.05 mm Hg•s) were significantly higher than that in controls (11.01 ± 3.67 mm Hg•s, both P &lt; 0.001). During a median follow-up of 9.9 years, 56 deaths occurred. XSPI was a significant independent predictor of total mortality after adjusting for age, sex, left ventricular ejection fraction (LVEF), glomerular filtration rate (GFR), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (hazard ratio = 4.37 per 1 SD, 95% confidence interval, 1.31-14.58). In subgroup analysis by different baseline characteristics including age, gender, NT-proBNP, LVEF, and GFR, higher XSPI was consistently associated with greater risk of total mortality. 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XSPI was a significant independent predictor of total mortality after adjusting for age, sex, left ventricular ejection fraction (LVEF), glomerular filtration rate (GFR), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (hazard ratio = 4.37 per 1 SD, 95% confidence interval, 1.31-14.58). In subgroup analysis by different baseline characteristics including age, gender, NT-proBNP, LVEF, and GFR, higher XSPI was consistently associated with greater risk of total mortality. 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subjects Adult
Age Factors
Aged
Aged, 80 and over
Blood Pressure
Carotid Arteries - physiopathology
Female
Heart Failure - mortality
Humans
Hypertension - mortality
Male
Manometry
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Predictive Value of Tests
Prognosis
Prospective Studies
Sex Factors
Stroke Volume
Taiwan - epidemiology
Wavelet Analysis
title Excess Pressure Integral Predicts Long-Term All-Cause Mortality in Stable Heart Failure Patients
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