Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas
Chordomas in children and adolescents are rare, and minimal published information is available. Our aim was to research clinical features and prognostic factors associated with clival chordomas in younger patients. The study included 25 patients (10 males and 15 females). Average follow-up time was...
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| Veröffentlicht in: | World neurosurgery 2017-02, Vol.98, p.323-328 |
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| creator | Zhai, Yixuan Bai, Jiwei Gao, Hua Wang, Shuai Li, Mingxuan Gui, Songbai Li, Chuzhong Zhang, Yazhuo |
| description | Chordomas in children and adolescents are rare, and minimal published information is available. Our aim was to research clinical features and prognostic factors associated with clival chordomas in younger patients.
The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2–108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score |
| doi_str_mv | 10.1016/j.wneu.2016.11.015 |
| format | Article |
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The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2–108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score <90 (P = 0.041) and patients in the nontotal resection group (P = 0.0497). Patients with lower Ki-67 expression levels had longer OS (P = 0.0207). Progression-free survival of patients with lower CK8 expression levels was significantly longer compared with patients with higher CK8 levels (P = 0.008). Expression levels of platelet-derived growth factor receptor-β were significantly correlated with expression levels of brachyury (P = 0.016).
In children and adolescents with clival chordomas, higher preoperative Karnofsky performance scale score, total resection, and lower levels of Ki-67 and CK8 expression are favorable prognostic factors. Platelet-derived growth factor receptor-β may play a role in tumorigenesis and epithelial-mesenchymal transition of clival chordomas.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2016.11.015</identifier><identifier>PMID: 27838423</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Child ; Children ; Chordoma ; Chordoma - diagnostic imaging ; Chordoma - surgery ; Cranial Fossa, Posterior - diagnostic imaging ; Cranial Fossa, Posterior - surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis ; Skull base ; Skull Base Neoplasms - diagnostic imaging ; Skull Base Neoplasms - surgery ; Young Adult</subject><ispartof>World neurosurgery, 2017-02, Vol.98, p.323-328</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-cafa49f825b09f215e2fe8fdf42887dc3328c969a5b9ba726c7fdf44f211ad03</citedby><cites>FETCH-LOGICAL-c356t-cafa49f825b09f215e2fe8fdf42887dc3328c969a5b9ba726c7fdf44f211ad03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2016.11.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27838423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhai, Yixuan</creatorcontrib><creatorcontrib>Bai, Jiwei</creatorcontrib><creatorcontrib>Gao, Hua</creatorcontrib><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Li, Mingxuan</creatorcontrib><creatorcontrib>Gui, Songbai</creatorcontrib><creatorcontrib>Li, Chuzhong</creatorcontrib><creatorcontrib>Zhang, Yazhuo</creatorcontrib><title>Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Chordomas in children and adolescents are rare, and minimal published information is available. Our aim was to research clinical features and prognostic factors associated with clival chordomas in younger patients.
The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2–108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score <90 (P = 0.041) and patients in the nontotal resection group (P = 0.0497). Patients with lower Ki-67 expression levels had longer OS (P = 0.0207). Progression-free survival of patients with lower CK8 expression levels was significantly longer compared with patients with higher CK8 levels (P = 0.008). Expression levels of platelet-derived growth factor receptor-β were significantly correlated with expression levels of brachyury (P = 0.016).
In children and adolescents with clival chordomas, higher preoperative Karnofsky performance scale score, total resection, and lower levels of Ki-67 and CK8 expression are favorable prognostic factors. Platelet-derived growth factor receptor-β may play a role in tumorigenesis and epithelial-mesenchymal transition of clival chordomas.</description><subject>Adolescent</subject><subject>Child</subject><subject>Children</subject><subject>Chordoma</subject><subject>Chordoma - diagnostic imaging</subject><subject>Chordoma - surgery</subject><subject>Cranial Fossa, Posterior - diagnostic imaging</subject><subject>Cranial Fossa, Posterior - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Prognosis</subject><subject>Skull base</subject><subject>Skull Base Neoplasms - diagnostic imaging</subject><subject>Skull Base Neoplasms - surgery</subject><subject>Young Adult</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EolXpH2BAGVkaYjsfjsRSRRSQKsHQicVy7DN1lcTFTlrx73Fp6cgtd5Kfe3R-EbrFSYwTnD9s4n0HQ0zCHGMcJzi7QGPMCjZjRV5enucsGaGp95skFMUpK-g1GpGCUZYSOkYfVWM6I0UTLUD0gwMfiU5F785-dtb3RkYLIXvrfGR1VK1Noxx0v8hc2Qa8hK730d706yiYdsFTra1TthX-Bl1p0XiYnvoErRZPq-pltnx7fq3my5mkWd7PpNAiLTUjWZ2UmuAMiAamlU4JY4WSlBImy7wUWV3WoiC5LA6PaUCxUAmdoPujduvs1wC-560JZzWN6MAOnmNGS4wJzdKAkiMqnfXegeZbZ1rhvjlO-CFVvuGHVPkhVY4xD6mGpbuTf6hbUOeVvwwD8HgEIHxyZ8BxLw10EpRxIHuurPnP_wPFq4lq</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Zhai, Yixuan</creator><creator>Bai, Jiwei</creator><creator>Gao, Hua</creator><creator>Wang, Shuai</creator><creator>Li, Mingxuan</creator><creator>Gui, Songbai</creator><creator>Li, Chuzhong</creator><creator>Zhang, Yazhuo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas</title><author>Zhai, Yixuan ; Bai, Jiwei ; Gao, Hua ; Wang, Shuai ; Li, Mingxuan ; Gui, Songbai ; Li, Chuzhong ; Zhang, Yazhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-cafa49f825b09f215e2fe8fdf42887dc3328c969a5b9ba726c7fdf44f211ad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Children</topic><topic>Chordoma</topic><topic>Chordoma - diagnostic imaging</topic><topic>Chordoma - surgery</topic><topic>Cranial Fossa, Posterior - diagnostic imaging</topic><topic>Cranial Fossa, Posterior - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Prognosis</topic><topic>Skull base</topic><topic>Skull Base Neoplasms - diagnostic imaging</topic><topic>Skull Base Neoplasms - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhai, Yixuan</creatorcontrib><creatorcontrib>Bai, Jiwei</creatorcontrib><creatorcontrib>Gao, Hua</creatorcontrib><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Li, Mingxuan</creatorcontrib><creatorcontrib>Gui, Songbai</creatorcontrib><creatorcontrib>Li, Chuzhong</creatorcontrib><creatorcontrib>Zhang, Yazhuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhai, Yixuan</au><au>Bai, Jiwei</au><au>Gao, Hua</au><au>Wang, Shuai</au><au>Li, Mingxuan</au><au>Gui, Songbai</au><au>Li, Chuzhong</au><au>Zhang, Yazhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2017-02</date><risdate>2017</risdate><volume>98</volume><spage>323</spage><epage>328</epage><pages>323-328</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Chordomas in children and adolescents are rare, and minimal published information is available. Our aim was to research clinical features and prognostic factors associated with clival chordomas in younger patients.
The study included 25 patients (10 males and 15 females). Average follow-up time was 42.95 months (range, 2–108 months). Kaplan-Meier analysis was used to determine overall survival (OS) and progression-free survival. Pearson correlation was used to perform correlation analysis. Immunohistochemistry was used to detect Ki-67, cytokeratin 8 (CK8), platelet-derived growth factor receptor-β, and brachyury expression levels.
Average age (± SD) of patients was 14.44 (3.44) years. Total resection was achieved in 5 cases, and nontotal resection was achieved in 20 cases. Average OS of patients with Karnofsky performance scale score ≥90 and patients in the total resection group was significantly longer compared with OS of patients with Karnofsky performance scale score <90 (P = 0.041) and patients in the nontotal resection group (P = 0.0497). Patients with lower Ki-67 expression levels had longer OS (P = 0.0207). Progression-free survival of patients with lower CK8 expression levels was significantly longer compared with patients with higher CK8 levels (P = 0.008). Expression levels of platelet-derived growth factor receptor-β were significantly correlated with expression levels of brachyury (P = 0.016).
In children and adolescents with clival chordomas, higher preoperative Karnofsky performance scale score, total resection, and lower levels of Ki-67 and CK8 expression are favorable prognostic factors. Platelet-derived growth factor receptor-β may play a role in tumorigenesis and epithelial-mesenchymal transition of clival chordomas.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27838423</pmid><doi>10.1016/j.wneu.2016.11.015</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Child Children Chordoma Chordoma - diagnostic imaging Chordoma - surgery Cranial Fossa, Posterior - diagnostic imaging Cranial Fossa, Posterior - surgery Female Follow-Up Studies Humans Male Prognosis Skull base Skull Base Neoplasms - diagnostic imaging Skull Base Neoplasms - surgery Young Adult |
| title | Clinical Features and Prognostic Factors of Children and Adolescents with Clival Chordomas |
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