Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

Recent research demonstrates that the choline-derived metabolite trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis and cardiovascular risks. The NLRP3 inflammasome responds to exogenous and endogenous danger signals involved in the development of atherosclerosis. More...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-12, Vol.481 (1-2), p.63-70
Hauptverfasser:	Sun, Xiaolei, Jiao, Xuefei, Ma, Yarong, Liu, Yong, Zhang, Lei, He, Yanzheng, Chen, Yunhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Carrier Proteins - immunology Cells, Cultured Dose-Response Relationship, Drug Endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - immunology Humans Inflammasomes - immunology Inflammation - chemically induced Inflammation - immunology Methylamines - adverse effects NLR Family, Pyrin Domain-Containing 3 Protein - immunology NLRP3 inflammasome Oxidative stress Reactive Oxygen Species - immunology Trimethylamine N-oxide
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