EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

The epidermal growth factor receptor (EGFR) represents one of the most common target proteins in anti-cancer therapy. To directly examine the structural and dynamical properties of EGFR activation by the epidermal growth factor (EGF) in native membranes, we have developed a solid-state nuclear magne...

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Veröffentlicht in:	Cell 2016-11, Vol.167 (5), p.1241-1251.e11
Hauptverfasser:	Kaplan, Mohammed, Narasimhan, Siddarth, de Heus, Cecilia, Mance, Deni, van Doorn, Sander, Houben, Klaartje, Popov-Čeleketić, Dušan, Damman, Reinier, Katrukha, Eugene A., Jain, Purvi, Geerts, Willie J.C., Heck, Albert J.R., Folkers, Gert E., Kapitein, Lukas C., Lemeer, Simone, van Bergen en Henegouwen, Paul M.P., Baldus, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	activation cancer Cell Line, Tumor EGFR Epidermal Growth Factor - metabolism Humans Intracellular Membranes - chemistry membrane protein NMR Nuclear Magnetic Resonance, Biomolecular Protein Multimerization receptor Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - isolation & purification Receptor, Epidermal Growth Factor - metabolism Solid-state NMR Thermodynamics Transport Vesicles - chemistry tyrosine kinase
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