A new classification method for MALDI imaging mass spectrometry data acquired on formalin-fixed paraffin-embedded tissue samples

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) shows a high potential for applications in histopathological diagnosis, and in particular for supporting tumor typing and subtyping. The development of such applications requires the extraction of spectral fingerprints...

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Veröffentlicht in:	Biochimica et biophysica acta. Proteins and proteomics 2017-07, Vol.1865 (7), p.916-926
Hauptverfasser:	Boskamp, Tobias, Lachmund, Delf, Oetjen, Janina, Cordero Hernandez, Yovany, Trede, Dennis, Maass, Peter, Casadonte, Rita, Kriegsmann, Jörg, Warth, Arne, Dienemann, Hendrik, Weichert, Wilko, Kriegsmann, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Characteristic spectral patterns Classification Feature extraction Formaldehyde - chemistry Formalin-fixed paraffin-embedded Humans Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - pathology MALDI imaging MS Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Paraffin - chemistry Peptides - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Tissue Array Analysis - methods Tumor typing
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