Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

Altered redox status in cancer cells has been linked to lipid peroxidation induced by reactive oxygen species (ROS) and subsequent formation of reactive lipid electrophiles, especially 4-hydroxy-nonenal (4-HNE). Emerging evidence suggests that cancer cells manipulate redox status to acquire anti-apo...

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Veröffentlicht in:	Free radical biology & medicine 2017-01, Vol.102, p.67-76
Hauptverfasser:	Zhong, Huiqin, Xiao, Mengqing, Zarkovic, Kamelija, Zhu, Mingjiang, Sa, Rina, Lu, Jianhong, Tao, Yongzhen, Chen, Qun, Xia, Lin, Cheng, Shuqun, Waeg, Georg, Zarkovic, Neven, Yin, Huiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxy-2-nonenal Aldehydes - metabolism Apoptosis Apoptosis - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cardiolipin Cardiolipins - genetics Cardiolipins - metabolism Hepatocellular carcinoma Humans Lipid Peroxidation - genetics Lipids - chemistry Lipids - genetics Liver - metabolism Liver - pathology Liver Neoplasms - metabolism Liver Neoplasms - pathology Mitochondria - metabolism Mitochondria - pathology Mitochondrial Membranes - metabolism Mitochondrial Membranes - pathology Oxidation-Reduction Oxidative stress Oxidative Stress - genetics Reactive Oxygen Species - metabolism
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