Cortical bone analysis in a predialysis population: a comparison with a dialysis population
This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical b...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2017-09, Vol.35 (5), p.513-521 |
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| creator | Carvalho, Catarina Magalhães, J. Neto, R. Pereira, L. Branco, P. Adragão, T. Frazão, J. M. |
| description | This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters. Predialysis patients compared with dialysis patients showed increased cortical bone thickness (
p
= 0.027) and decreased osteonal bone formation rate (
p
= 0.020) and adjusted apposition rate (
p
= 0.018), mainly for external cortical bone. In this predialysis population, trabecular bone volume positively correlated with external cortical porosity (
r
= 0.723,
p
= 0.003), external cortical thickness (
r
= 0.569,
p
= 0.034), and external osteonal accumulation (osteonal osteoid thickness,
r
= 0.530,
p
= 0.05; osteonal osteoid volume to bone volume ratio,
r
= 0.921,
p
|
| doi_str_mv | 10.1007/s00774-016-0781-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1839108870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1936760954</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-8f6ccf83dfe287fa27d3e910a2415f5f6462d5427ae3f9373ee895bc74a85df23</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuXaNJ8e5PFLxC86MlDyLaJZuk2NWmR_fdm6SoiepmBmWfekAeAY4zOMULiIuUiKESYQyQkhnIHTDElDDKO6C6YIoUplEKoCThIaYkQFkzgfTAphSSISDIFL_MQe1-ZpliE1hamNc06-VT4tjBFF23tt4MudENjeh_ay7ypwqoz0afQFh--f8uTP8BDsOdMk-zRts_A88310_wOPjze3s-vHmBFFO-hdLyqnCS1s6UUzpSiJlZhZEqKmWOOU17WjJbCWOIUEcRaqdiiEtRIVruSzMDZmNvF8D7Y1OuVT5VtGtPaMCSNJclxUgqU0dNf6DIMMX86U4pwwZFiNFN4pKoYUorW6S76lYlrjZHemNejeZ3N6415LfPNyTZ5WKxs_X3xpToD5QikvGpfbfzx9L-pn-VEjqY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1936760954</pqid></control><display><type>article</type><title>Cortical bone analysis in a predialysis population: a comparison with a dialysis population</title><source>SpringerNature Journals</source><creator>Carvalho, Catarina ; Magalhães, J. ; Neto, R. ; Pereira, L. ; Branco, P. ; Adragão, T. ; Frazão, J. M.</creator><creatorcontrib>Carvalho, Catarina ; Magalhães, J. ; Neto, R. ; Pereira, L. ; Branco, P. ; Adragão, T. ; Frazão, J. M.</creatorcontrib><description>This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters. Predialysis patients compared with dialysis patients showed increased cortical bone thickness (
p
= 0.027) and decreased osteonal bone formation rate (
p
= 0.020) and adjusted apposition rate (
p
= 0.018), mainly for external cortical bone. In this predialysis population, trabecular bone volume positively correlated with external cortical porosity (
r
= 0.723,
p
= 0.003), external cortical thickness (
r
= 0.569,
p
= 0.034), and external osteonal accumulation (osteonal osteoid thickness,
r
= 0.530,
p
= 0.05; osteonal osteoid volume to bone volume ratio,
r
= 0.921,
p
< 0.001; and osteonal osteoid surface to bone surface ratio,
r
= 0.631,
p
= 0.016). These correlations were not observed in the internal cortical bone. Cortical osteonal mineralization surface negatively correlated with DXA
Z
and
T
scores and bone mineral density for the distal end of the forearm. The osteonal bone formation rate of both internal cortical bone and external cortical bone correlated with
Z
score (
r
= −0.975,
p
= 0.005 and
r
= −0.880,
p
= 0.021 respectively). We found no significant correlations between cortical thickness or porosity and DXA parameters for either external cortical bone or internal cortical bone. Our results suggest that a greater degree of kidney disease is associated with thinner cortices, eventually contributing to the higher fracture rate observed in the chronic kidney disease population. In predialysis patients, parathyroid hormone seems to have a modulating effect on both trabecular bone and cortical bone, particularly in external cortical bone.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-016-0781-8</identifier><identifier>PMID: 27830383</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Apposition ; Bone growth ; Bone histomorphometry ; Bone mineral density ; Cancellous bone ; Cortical bone ; Dialysis ; Dual energy X-ray absorptiometry ; Females ; Forearm ; Hemodialysis ; Kidney diseases ; Kidney transplantation ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mineralization ; Original Article ; Orthopedics ; Osteogenesis ; Osteoid ; Parathyroid ; Parathyroid hormone ; Population ; Population studies ; Porosity</subject><ispartof>Journal of bone and mineral metabolism, 2017-09, Vol.35 (5), p.513-521</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2016</rights><rights>Journal of Bone and Mineral Metabolism is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-8f6ccf83dfe287fa27d3e910a2415f5f6462d5427ae3f9373ee895bc74a85df23</citedby><cites>FETCH-LOGICAL-c396t-8f6ccf83dfe287fa27d3e910a2415f5f6462d5427ae3f9373ee895bc74a85df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-016-0781-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-016-0781-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27830383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho, Catarina</creatorcontrib><creatorcontrib>Magalhães, J.</creatorcontrib><creatorcontrib>Neto, R.</creatorcontrib><creatorcontrib>Pereira, L.</creatorcontrib><creatorcontrib>Branco, P.</creatorcontrib><creatorcontrib>Adragão, T.</creatorcontrib><creatorcontrib>Frazão, J. M.</creatorcontrib><title>Cortical bone analysis in a predialysis population: a comparison with a dialysis population</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters. Predialysis patients compared with dialysis patients showed increased cortical bone thickness (
p
= 0.027) and decreased osteonal bone formation rate (
p
= 0.020) and adjusted apposition rate (
p
= 0.018), mainly for external cortical bone. In this predialysis population, trabecular bone volume positively correlated with external cortical porosity (
r
= 0.723,
p
= 0.003), external cortical thickness (
r
= 0.569,
p
= 0.034), and external osteonal accumulation (osteonal osteoid thickness,
r
= 0.530,
p
= 0.05; osteonal osteoid volume to bone volume ratio,
r
= 0.921,
p
< 0.001; and osteonal osteoid surface to bone surface ratio,
r
= 0.631,
p
= 0.016). These correlations were not observed in the internal cortical bone. Cortical osteonal mineralization surface negatively correlated with DXA
Z
and
T
scores and bone mineral density for the distal end of the forearm. The osteonal bone formation rate of both internal cortical bone and external cortical bone correlated with
Z
score (
r
= −0.975,
p
= 0.005 and
r
= −0.880,
p
= 0.021 respectively). We found no significant correlations between cortical thickness or porosity and DXA parameters for either external cortical bone or internal cortical bone. Our results suggest that a greater degree of kidney disease is associated with thinner cortices, eventually contributing to the higher fracture rate observed in the chronic kidney disease population. In predialysis patients, parathyroid hormone seems to have a modulating effect on both trabecular bone and cortical bone, particularly in external cortical bone.</description><subject>Apposition</subject><subject>Bone growth</subject><subject>Bone histomorphometry</subject><subject>Bone mineral density</subject><subject>Cancellous bone</subject><subject>Cortical bone</subject><subject>Dialysis</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Females</subject><subject>Forearm</subject><subject>Hemodialysis</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mineralization</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteogenesis</subject><subject>Osteoid</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Population</subject><subject>Population studies</subject><subject>Porosity</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuXaNJ8e5PFLxC86MlDyLaJZuk2NWmR_fdm6SoiepmBmWfekAeAY4zOMULiIuUiKESYQyQkhnIHTDElDDKO6C6YIoUplEKoCThIaYkQFkzgfTAphSSISDIFL_MQe1-ZpliE1hamNc06-VT4tjBFF23tt4MudENjeh_ay7ypwqoz0afQFh--f8uTP8BDsOdMk-zRts_A88310_wOPjze3s-vHmBFFO-hdLyqnCS1s6UUzpSiJlZhZEqKmWOOU17WjJbCWOIUEcRaqdiiEtRIVruSzMDZmNvF8D7Y1OuVT5VtGtPaMCSNJclxUgqU0dNf6DIMMX86U4pwwZFiNFN4pKoYUorW6S76lYlrjZHemNejeZ3N6415LfPNyTZ5WKxs_X3xpToD5QikvGpfbfzx9L-pn-VEjqY</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Carvalho, Catarina</creator><creator>Magalhães, J.</creator><creator>Neto, R.</creator><creator>Pereira, L.</creator><creator>Branco, P.</creator><creator>Adragão, T.</creator><creator>Frazão, J. M.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Cortical bone analysis in a predialysis population: a comparison with a dialysis population</title><author>Carvalho, Catarina ; Magalhães, J. ; Neto, R. ; Pereira, L. ; Branco, P. ; Adragão, T. ; Frazão, J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-8f6ccf83dfe287fa27d3e910a2415f5f6462d5427ae3f9373ee895bc74a85df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apposition</topic><topic>Bone growth</topic><topic>Bone histomorphometry</topic><topic>Bone mineral density</topic><topic>Cancellous bone</topic><topic>Cortical bone</topic><topic>Dialysis</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Females</topic><topic>Forearm</topic><topic>Hemodialysis</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mineralization</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteogenesis</topic><topic>Osteoid</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Population</topic><topic>Population studies</topic><topic>Porosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, Catarina</creatorcontrib><creatorcontrib>Magalhães, J.</creatorcontrib><creatorcontrib>Neto, R.</creatorcontrib><creatorcontrib>Pereira, L.</creatorcontrib><creatorcontrib>Branco, P.</creatorcontrib><creatorcontrib>Adragão, T.</creatorcontrib><creatorcontrib>Frazão, J. M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho, Catarina</au><au>Magalhães, J.</au><au>Neto, R.</au><au>Pereira, L.</au><au>Branco, P.</au><au>Adragão, T.</au><au>Frazão, J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical bone analysis in a predialysis population: a comparison with a dialysis population</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>35</volume><issue>5</issue><spage>513</spage><epage>521</epage><pages>513-521</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters. Predialysis patients compared with dialysis patients showed increased cortical bone thickness (
p
= 0.027) and decreased osteonal bone formation rate (
p
= 0.020) and adjusted apposition rate (
p
= 0.018), mainly for external cortical bone. In this predialysis population, trabecular bone volume positively correlated with external cortical porosity (
r
= 0.723,
p
= 0.003), external cortical thickness (
r
= 0.569,
p
= 0.034), and external osteonal accumulation (osteonal osteoid thickness,
r
= 0.530,
p
= 0.05; osteonal osteoid volume to bone volume ratio,
r
= 0.921,
p
< 0.001; and osteonal osteoid surface to bone surface ratio,
r
= 0.631,
p
= 0.016). These correlations were not observed in the internal cortical bone. Cortical osteonal mineralization surface negatively correlated with DXA
Z
and
T
scores and bone mineral density for the distal end of the forearm. The osteonal bone formation rate of both internal cortical bone and external cortical bone correlated with
Z
score (
r
= −0.975,
p
= 0.005 and
r
= −0.880,
p
= 0.021 respectively). We found no significant correlations between cortical thickness or porosity and DXA parameters for either external cortical bone or internal cortical bone. Our results suggest that a greater degree of kidney disease is associated with thinner cortices, eventually contributing to the higher fracture rate observed in the chronic kidney disease population. In predialysis patients, parathyroid hormone seems to have a modulating effect on both trabecular bone and cortical bone, particularly in external cortical bone.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27830383</pmid><doi>10.1007/s00774-016-0781-8</doi><tpages>9</tpages></addata></record> |
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| source | SpringerNature Journals |
| subjects | Apposition Bone growth Bone histomorphometry Bone mineral density Cancellous bone Cortical bone Dialysis Dual energy X-ray absorptiometry Females Forearm Hemodialysis Kidney diseases Kidney transplantation Medicine Medicine & Public Health Metabolic Diseases Mineralization Original Article Orthopedics Osteogenesis Osteoid Parathyroid Parathyroid hormone Population Population studies Porosity |
| title | Cortical bone analysis in a predialysis population: a comparison with a dialysis population |
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