Curcumin Suppresses Epithelial–Mesenchymal Transition of Renal Tubular Epithelial Cells through the Inhibition of Akt/mTOR Pathway

Curcumin has exhibited a protective effect against development of renal fibrosis in animal models, however, its underlying molecular mechanisms are largely unclear. Therefore, we investigated the anti-fibrosis effects of curcumin in transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenc...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/01/01, Vol.40(1), pp.17-24
Hauptverfasser:	Zhu, Fang-qiang, Chen, Min-jia, Zhu, Ming, Zhao, Rong-seng, Qiu, Wei, Xu, Xiang, Liu, Hong, Zhao, Hong-wen, Yu, Rong-jie, Wu, Xiong-fei, Zhang, Keqin, Huang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Actin Actins - genetics Actins - metabolism AKT protein Animal models Cadherins - genetics Cadherins - metabolism Calcium-Binding Proteins - metabolism Cell Line Cell proliferation Cell Survival - drug effects Curcumin Curcumin - pharmacology Cytokeratin E-cadherin Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects epithelial-to-mesenchymal transition Fibrosis Humans Immunocytochemistry Inhibition Keratins - genetics Keratins - metabolism Kidney Tubules, Proximal - cytology Kidneys Kinases mammalian target of rapamycin (mTOR) pathway Mesenchyme Molecular modelling Muscles Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rapamycin renal fibrosis renal tubular epithelial cell Smooth muscle TOR protein TOR Serine-Threonine Kinases - metabolism Transforming growth factor Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 transforming growth factor-β1 (TGF-β1) Vimentin Vimentin - genetics Vimentin - metabolism
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