Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis
Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP). From pr...
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| Veröffentlicht in: | Pancreas 2017-01, Vol.46 (1), p.77-82 |
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| creator | Nikkola, Anssi Aittoniemi, Janne Huttunen, Reetta Rajala, Linnea Nordback, Isto Sand, Juhani Laukkarinen, Johanna |
| description | Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP).
From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge.
According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%). Median P-suPAR levels were significantly higher in patients with AAP during hospitalization than after discharge (4.8 vs 3.1 ng/mL; P < 0.001) and in non-mild compared to mild AAP (6.2 vs 4.2 ng/mL; P < 0.001). When the analysis was made 1 to 4 days after admission (n = 68), the area under the curve was 0.81 (95% confidence interval, 0.70-0.92). P-suPAR was found to be a better prognostic marker in AAP than C-reactive protein, hematocrit, or creatinine.
P-suPAR concentrations are elevated in AAP and correlate with the severity of the disease. These results suggest that P-suPAR may have potential to serve as a novel prognostic marker for AAP severity on admission. |
| doi_str_mv | 10.1097/MPA.0000000000000730 |
| format | Article |
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From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge.
According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%). Median P-suPAR levels were significantly higher in patients with AAP during hospitalization than after discharge (4.8 vs 3.1 ng/mL; P < 0.001) and in non-mild compared to mild AAP (6.2 vs 4.2 ng/mL; P < 0.001). When the analysis was made 1 to 4 days after admission (n = 68), the area under the curve was 0.81 (95% confidence interval, 0.70-0.92). P-suPAR was found to be a better prognostic marker in AAP than C-reactive protein, hematocrit, or creatinine.
P-suPAR concentrations are elevated in AAP and correlate with the severity of the disease. These results suggest that P-suPAR may have potential to serve as a novel prognostic marker for AAP severity on admission.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/MPA.0000000000000730</identifier><identifier>PMID: 27841794</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Biomarkers - blood ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis, Alcoholic - blood ; Pancreatitis, Alcoholic - diagnosis ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator - blood ; ROC Curve ; Severity of Illness Index ; Young Adult</subject><ispartof>Pancreas, 2017-01, Vol.46 (1), p.77-82</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-fd04062c413f6d1fc0cecbfc062505eb49a1bb91f82acf533455c6570324c7c53</citedby><cites>FETCH-LOGICAL-c353t-fd04062c413f6d1fc0cecbfc062505eb49a1bb91f82acf533455c6570324c7c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27841794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikkola, Anssi</creatorcontrib><creatorcontrib>Aittoniemi, Janne</creatorcontrib><creatorcontrib>Huttunen, Reetta</creatorcontrib><creatorcontrib>Rajala, Linnea</creatorcontrib><creatorcontrib>Nordback, Isto</creatorcontrib><creatorcontrib>Sand, Juhani</creatorcontrib><creatorcontrib>Laukkarinen, Johanna</creatorcontrib><title>Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP).
From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge.
According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%). Median P-suPAR levels were significantly higher in patients with AAP during hospitalization than after discharge (4.8 vs 3.1 ng/mL; P < 0.001) and in non-mild compared to mild AAP (6.2 vs 4.2 ng/mL; P < 0.001). When the analysis was made 1 to 4 days after admission (n = 68), the area under the curve was 0.81 (95% confidence interval, 0.70-0.92). P-suPAR was found to be a better prognostic marker in AAP than C-reactive protein, hematocrit, or creatinine.
P-suPAR concentrations are elevated in AAP and correlate with the severity of the disease. These results suggest that P-suPAR may have potential to serve as a novel prognostic marker for AAP severity on admission.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatitis, Alcoholic - blood</subject><subject>Pancreatitis, Alcoholic - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Receptors, Urokinase Plasminogen Activator - blood</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Young Adult</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtKxDAUhoMoOl7eQCRLN9WkSZp2WcQbjDh4WZf0zKlGM82YpMK8vR1viGfzn8V_gY-QQ85OOKv06c2sPmF_Twu2QSZciSKTZV5ukgkrS5UJrvUO2Y3xhTGuhaq2yU6uS8l1JSdkNXMmLgyd4js66jt6793QOqSPwb_a3kTM0mqJ9NNme_-EPa0h2XeTfKB3CLhcP7OAcwsp0vSM9H7sCjat1nU1DAlp7cA_e0dnpoeAJtlk4z7Z6oyLePCte-Tx4vzh7Cqb3l5en9XTDIQSKevmTLIiB8lFV8x5BwwQ2lGKXDGFrawMb9uKd2VuoFNCSKWgUJqJXIIGJfbI8VfvMvi3AWNqFjYCOmd69ENseCkqzrQs-WiVX1YIPsaAXbMMdmHCquGsWUNvRujNf-hj7Oh7YWgXOP8N_VAWH9bafmQ</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Nikkola, Anssi</creator><creator>Aittoniemi, Janne</creator><creator>Huttunen, Reetta</creator><creator>Rajala, Linnea</creator><creator>Nordback, Isto</creator><creator>Sand, Juhani</creator><creator>Laukkarinen, Johanna</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis</title><author>Nikkola, Anssi ; Aittoniemi, Janne ; Huttunen, Reetta ; Rajala, Linnea ; Nordback, Isto ; Sand, Juhani ; Laukkarinen, Johanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-fd04062c413f6d1fc0cecbfc062505eb49a1bb91f82acf533455c6570324c7c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatitis, Alcoholic - blood</topic><topic>Pancreatitis, Alcoholic - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Receptors, Urokinase Plasminogen Activator - blood</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikkola, Anssi</creatorcontrib><creatorcontrib>Aittoniemi, Janne</creatorcontrib><creatorcontrib>Huttunen, Reetta</creatorcontrib><creatorcontrib>Rajala, Linnea</creatorcontrib><creatorcontrib>Nordback, Isto</creatorcontrib><creatorcontrib>Sand, Juhani</creatorcontrib><creatorcontrib>Laukkarinen, Johanna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikkola, Anssi</au><au>Aittoniemi, Janne</au><au>Huttunen, Reetta</au><au>Rajala, Linnea</au><au>Nordback, Isto</au><au>Sand, Juhani</au><au>Laukkarinen, Johanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2017-01</date><risdate>2017</risdate><volume>46</volume><issue>1</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP).
From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge.
According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%). Median P-suPAR levels were significantly higher in patients with AAP during hospitalization than after discharge (4.8 vs 3.1 ng/mL; P < 0.001) and in non-mild compared to mild AAP (6.2 vs 4.2 ng/mL; P < 0.001). When the analysis was made 1 to 4 days after admission (n = 68), the area under the curve was 0.81 (95% confidence interval, 0.70-0.92). P-suPAR was found to be a better prognostic marker in AAP than C-reactive protein, hematocrit, or creatinine.
P-suPAR concentrations are elevated in AAP and correlate with the severity of the disease. These results suggest that P-suPAR may have potential to serve as a novel prognostic marker for AAP severity on admission.</abstract><cop>United States</cop><pmid>27841794</pmid><doi>10.1097/MPA.0000000000000730</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Adolescent Adult Aged Biomarkers - blood Female Humans Male Middle Aged Pancreatitis, Alcoholic - blood Pancreatitis, Alcoholic - diagnosis Predictive Value of Tests Prognosis Prospective Studies Receptors, Urokinase Plasminogen Activator - blood ROC Curve Severity of Illness Index Young Adult |
| title | Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis |
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