Redox Properties of Met super(35) in Neurotoxic beta -Amyloid Peptide. A Molecular Modeling Study

The beta -amyloid peptide ( beta AP) is the principal component of plaque associated with the pathology of Alzheimer's disease. Part of its neurotoxicity appears to correlate with the ability of the peptide to reduce Cu super(II) and form free radicals. Both processes are dependent on the prese...

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Veröffentlicht in:Chemical research in toxicology 2002-03, Vol.15 (3), p.408-418
Hauptverfasser: Pogocki, D, Schoeneich, C
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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