Synaptic Mechanisms Underlie Nicotine-Induced Excitability of Brain Reward Areas

A single nicotine exposure increases dopamine levels in the mesolimbic reward system for hours, but nicotine concentrations experienced by smokers desensitize nAChRs on dopamine neurons in seconds to minutes. Here, we show that persistent modulation of both GABAergic and glutamatergic synaptic trans...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-03, Vol.33 (6), p.905-919
Hauptverfasser:	Mansvelder, Huibert D, Keath, J.Russel, McGehee, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Action Potentials - physiology Adolescent Animals Atropine - pharmacology Brain Brain research Cholinergic Antagonists - pharmacology Cholinesterase Inhibitors - pharmacology Dopamine - metabolism Electrophysiology Excitatory Amino Acid Antagonists - pharmacology Experiments gamma-Aminobutyric Acid - metabolism Ganglionic Stimulants - pharmacology Glutamic Acid - metabolism Humans In Vitro Techniques Insecticides - pharmacology Mice Muscarinic Antagonists - pharmacology Neurons Neurons - chemistry Neurons - drug effects Neurons - metabolism Nicotine Nicotine - pharmacology Organothiophosphorus Compounds - pharmacology Patch-Clamp Techniques Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, Nicotinic - metabolism Reward Rodents Smoking Software Synaptic Transmission - drug effects Synaptic Transmission - physiology Tobacco Ventral Tegmental Area - cytology Ventral Tegmental Area - physiology
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