Genotoxic Mechanism for the Major Acrolein-Derived Deoxyguanosine Adduct in Human Cells

Acrolein, widely distributed in the environment and also produced endogenously, forms deoxyguanosine adducts in DNA. The genotoxicity of the major acrolein-dG adduct, 8α and 8β isomers of 3H-8-hydroxy-3-(β-d-2‘-deoxyribofuranosyl)-5,6,7,8-tetrahydropyrido[3,2-a]purine-9-one (γ-OH-PdG), and the model...

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Veröffentlicht in:	Chemical research in toxicology 2002-02, Vol.15 (2), p.160-164
Hauptverfasser:	Yang, In-Young, Johnson, Francis, Grollman, Arthur P, Moriya, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - metabolism Acrolein - pharmacology Base Sequence Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Deoxyguanosine - pharmacology DNA Adducts - drug effects DNA Adducts - metabolism DNA Damage HeLa Cells - drug effects Humans Molecular Sequence Data Mutagens - metabolism Mutagens - pharmacology
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