VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis

In the RIP1-Tag2 mouse model of pancreatic islet carcinoma, angiogenesis is switched on in a discrete premalignant stage of tumor development, persisting thereafter. Signaling through VEGF receptor tyrosine kinases is a well-established component of angiogenic regulation. We show that five VEGF liga...

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Veröffentlicht in:	Cancer cell 2002-03, Vol.1 (2), p.193-202
Hauptverfasser:	Inoue, Masahiro, Hager, Jeffrey H, Ferrara, Napoleone, Gerber, Hans-Peter, Hanahan, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Gene Deletion Gene Expression Profiling GTPase-Activating Proteins - metabolism Humans Islets of Langerhans - blood supply Islets of Langerhans - metabolism Islets of Langerhans - pathology Lymphokines - genetics Lymphokines - metabolism Mice Mice, Transgenic Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Organ Specificity Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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